Journal ArticleDOI
Formulation of a morphine implantation pellet suitable for tolerance-physical dependence studies in mice.
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This article is published in Journal of Pharmaceutical Sciences.The article was published on 1970-03-01. It has received 219 citations till now.read more
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Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats.
TL;DR: The administration of the NMDA receptor antagonist, MK-801, to rats withdrawn from chronic ethanol, morphine or amphetamine, but not from chronic cocaine, readily reversed the fall in DA output and the reduction in extracellular DA during ethanol withdrawal.
Journal ArticleDOI
Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats
TL;DR: In rats implanted subcutaneously with morphine containing pellets different degrees of dependence were induced by varying the dosage, frequency of implantation and duration of exposure to morphine, and some signs became progressively more pronounced when dependence got stronger or the dose of the antagonist was increased.
Journal ArticleDOI
Drug reinforcement studied by the use of place conditioning in rat.
TL;DR: It was concluded that place conditioning produced by morphine and naloxone is mediated by specific opiate receptors and that stimulating and decreasing activity of the endogenous opioid peptide system with systemically administered drugs is positively reinforcing and aversive, respectively.
Journal ArticleDOI
beta-endorphin is a potent analgesic agent.
TL;DR: Beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats.
Journal ArticleDOI
Narcotic receptor sites in morphine-dependent rats.
TL;DR: Data is presented which effectively rule out the possibility that a direct adaptation takes place in which the number of receptor sites for the narcotics is greatly increased, or their affinities greatly reduced so that large amounts of drugs are needed to fill the available sites and thus effect a response.
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Journal Article
Simultaneous quantitative assessment of morphine tolerance and physical dependence
E. L. Way,Horace H. Loh,Shen Fh +2 more
TL;DR: Simultaneous assessment of morphine tolerance and physical dependence development and disappearance indicates a close relationship between the two syndromes and suggests that a common underlying mechanism may be involved.
Journal ArticleDOI
Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine.
TL;DR: Inhibition of this synthesis of brain 5-hydroxytryptamine with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.
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Simultaneous quantitative assessment of morphine tolerance and physical dependence
E. L. Way,Horace H. Loh,Shen Fh +2 more