Open AccessJournal Article
Fractionation and Purification of the Polysaccharides with Marked Antitumor Activity, Especially Lentinan, from Lentinus edodes (Berk.) Sing. (an Edible Mushroom)
TLDR
The first two polysaccharide preparations have a strong antitumor effect; lentinan, especially, markedly inhibited the growth of Sarcoma 180 implanted s.c. in mice, inducing almost complete regression of tumors at doses of 1 mg/kg × 10 with no sign of toxicity.Abstract:
Summary Six polysaccharide preparations, lentinan, LC-11, LC-12, LC-13, EC-11, and EC-14, were isolated from the water-soluble extracts of Lentinus edodes (Berk.) Sing., an edible mushroom, by fractional precipitation with ethanol and cetyltrimethylammonium hydroxide, fractional solubilization with acetic acid, and diethylaminoethyl cellulose column chromatography. The first two polysaccharide preparations have a strong antitumor effect; lentinan, especially, markedly inhibited the growth of Sarcoma 180 implanted s.c. in mice, inducing almost complete regression of tumors at doses of 1 mg/kg × 10 with no sign of toxicity. LC-11 was also effective in 5 to 25 mg/kg × 10 doses. The purity and properties of these antitumor polysaccharides are discussed.read more
Citations
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Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides.
TL;DR: The present review analyzes the pecularities of polysaccharides derived from fruiting bodies and cultured mycelium in selected examples of medicinal mushrooms and concludes that high molecular weight glucans appear to be more effective than those of low molecular weight.
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Free radical scavenging activities of mushroom polysaccharide extracts
F. Liu,V.E.C. Ooi,S. T. Chang +2 more
TL;DR: The superoxide and hydroxyl radical scavenging activities of eight mushroom antitumor polysaccharide extracts were investigated using phenazin methosulphate-NADH-nitroblue tetrazolium system and ascorbic acid-Cu(2+)-cytochrome C system respectively.
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Main properties and current applications of some polysaccharides as biomaterials
TL;DR: The main polysaccharides currently used in the biomedical and pharmaceutical domains are chitin and its derivative chitosan, hyaluronan, and alginates.
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Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity
TL;DR: The role of polysaccharides as an antitumor agent is especially under intense debate as discussed by the authors, and the current status of this research area with a view for future direction.
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Marine Polysaccharides in Pharmaceutical Applications: An Overview
TL;DR: This review will focus on possible strategies for chemical or physical modification aimed to tailor the final properties of interest in marine polysaccharides.
References
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Journal ArticleDOI
Inhibition of Mouse Sarcoma 180 by Polysaccharides from Lentinus edodes (Berk.) Sing.
TL;DR: POLYSACCHARIDE preparations from bamboo leaves, bagasse2,3 and wheat straw inhibit the growth of sarcoma 180 implanted subcutaneously in mice and it was proposed that this activity was host mediated, not cytocidal.
Journal ArticleDOI
Immune specific induction of interferon production in cultures of human blood lymphocytes.
TL;DR: The quantity of interferon produced by antigen stimulation was related to concentration of antigen over a relatively narrow range; with higher concentrations induction was decreased, and phytohemagglutinin-induced Interferon was primarily produced during the first 4 days in culture.
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Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.
TL;DR: The present report describes the isolation and characterization of a double-stranded RNA from extracts of Penicillium funiculosum (helenine) which, when freed of protein, is a highly active inducer of interferon and host resistance.
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