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Journal ArticleDOI

From Clocks to Chaos: The Rhythms of Life

Leon Glass, +2 more
- 01 Jan 1988 - 
- Vol. 42, Iss: 7, pp 72-72
TLDR
One of the most interesting features of the book is that it makes a start at explaining "dynamical diseases" that are not the result of infection by pathogens but that stem from abnormalities in the timing of essential functions.
Abstract
In an important new contribution to the literature of chaos, two distinguished researchers in the field of physiology probe central theoretical questions about physiological rhythms. Topics discussed include: How are rhythms generated? How do they start and stop? What are the effects of perturbation of the rhythms? How are oscillations organized in space? Leon Glass and Michael Mackey address an audience of biological scientists, physicians, physical scientists, and mathematicians, but the work assumes no knowledge of advanced mathematics. Variation of rhythms outside normal limits, or appearance of new rhythms where none existed previously, are associated with disease. One of the most interesting features of the book is that it makes a start at explaining "dynamical diseases" that are not the result of infection by pathogens but that stem from abnormalities in the timing of essential functions. From Clocks to Chaos provides a firm foundation for understanding dynamic processes in physiology.

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Citations
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Journal ArticleDOI

PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals.

TL;DR: The newly inaugurated Research Resource for Complex Physiologic Signals (RRSPS) as mentioned in this paper was created under the auspices of the National Center for Research Resources (NCR Resources).
Book

At Home in the Universe: The Search for the Laws of Self-Organization and Complexity

TL;DR: Complexity theory is one of the most controversial areas of current scientific research as mentioned in this paper, which suggests that there are hidden tendencies in nature to select ordered states, even when statistically they are vastly outnumbered by chaotic possibilities.
Journal ArticleDOI

Synchronization of pulse-coupled biological oscillators

TL;DR: A simple model for synchronous firing of biological oscillators based on Peskin's model of the cardiac pacemaker is studied in this article, which consists of a population of identical integrate-and-fire oscillators, whose coupling between oscillators is pulsatile: when a given oscillator fires, it pulls the others up by a fixed amount, or brings them to the firing threshold, whichever is less.
Journal ArticleDOI

Fractal dynamics in physiology: Alterations with disease and aging

TL;DR: Application of fractal analysis may provide new approaches to assessing cardiac risk and forecasting sudden cardiac death, as well as to monitoring the aging process, and similar approaches show promise in assessing other regulatory systems, such as human gait control in health and disease.
Journal ArticleDOI

Epidemiology and the web of causation: Has anyone seen the spider?

TL;DR: To better integrate biologic and social understandings of current and changing population patterns of health and disease, the essay proposes an ecosocial framework for developing epidemiologic theory.