Functional imaging and the neurobiology of the psychoses
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TLDR
The neurobiology of the psychoses has been a controversial issue and functional imaging techniques now provide a powerful tool to address critical questions concerning their fundamental nature.About:
This article is published in Seminars in Neuroscience.The article was published on 1995-06-01 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Functional imaging.read more
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Abnormal neural integration related to cognition in schizophrenia.
Abstract: A striking feature of schizophrenia is the diversity of the phenomenology both within and between patients. This diversity can be contrasted with the well-circumscribed and stable deficits seen in classic neuropsychological syndromes. The argument will be advanced that the classic lesion model, based on the notion of a segregated deficit, is inappropriate in schizophrenia. Instead the idea will be developed that a more appropriate model is one derived from concepts of neural integration across large-scale brain networks. Empirical data derived from positron emission tomography (PET) within our laboratory that provide support for this suggestion will be presented. One critical observation from these data is a disruption of prefrontal-temporal interactions, under a variety of cognitive activation paradigms, in both chronic medicated and acute unmedicated schizophrenic patients. Furthermore, these data indicate that both regional and interregional neuronal function, including prefrontal-temporal interactions, can be significantly modulated by a neurochemical perturbation of ascending dopaminergic systems. The latter observations suggest that the deficit of abnormal cortico-cortical interactions are to some extent modifiable by neuromodulatory neurotransmitter systems.
Journal ArticleDOI
NEURODEVELOPMENTAL AND NEUROPROGRESSIVE PROCESSES IN SCHIZOPHRENIA: Antithetical or Complementary, Over a Lifetime Trajectory of Disease?
John L. Waddington,John L. Waddington,A. Lane,Paul Scully,Conall Larkin,Conall Larkin,Eadbhard O'Callaghan +6 more
TL;DR: This article critically reviews the preponderance of evidence for each model of schizophrenia and provides an account of how these may interact or synergize to produce the characteristic clinical expression of schizophrenia.