Journal ArticleDOI
G-6-PD deficiency and malaria in Black Americans in Vietnam.
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TLDR
The study undertaken in black Americans in Vietnam to determine whether G-6-PD deficiency has any influence on malarial incidence or the clinical severity of malarial infections suggested that G- 6-PD deficient males might have milder cases of malaria, or even have an overall lower incidence of malaria infection.Abstract:
: Although the sickle-cell gene in Negro populations has been proven to confer resistance to malarial infection, other genetic markers occurring predominantly in Negroes, including glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, have not been shown to be associated with a lower incidence of Malaria. Human females heterozygous for G-6-PD deficiency, which is a sex-linked gene, have a mosaicism of red cells, and those cells deficient in G-6-PD were shown less likely to harbor P. falciparum parasites during an infection. This suggests that G-6-PD deficient males when compared with G-6-PD normal males might have milder cases of malaria, or perhaps even have an overall lower incidence of malaria infection. The study was undertaken in black Americans in Vietnam to determine whether G-6-PD deficiency has any influence on malarial incidence or the clinical severity of malarial infections.read more
Citations
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Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency.
TL;DR: It is shown that the red cells of more than 200 million people are deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD), and some once- accepted concepts concerning the relation between G6PD deficiency and hemolysis have changed.
Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency and malaria
C. Ruwende,Adrian V. S. Hill +1 more
TL;DR: Results from large case control studies conducted in East and West Africa provide strong evidence that the most common African G6PD deficiency variant, G6 PD A–, is associated with a significant reduction in the risk of severe malaria for both G 6PD female heterozygotes and male hemizygotes.
Journal ArticleDOI
Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
Taane G. Clark,Andrew E. Fry,Sarah Auburn,Susana Campino,Mahamadou Diakite,Angela Green,Anna Richardson,Yik Y. Teo,Kerrin S. Small,Jonathan Wilson,Muminatou Jallow,Fatou Sisay-Joof,Margaret Pinder,Pardis C. Sabeti,Pardis C. Sabeti,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Kirk A. Rockett +17 more
TL;DR: The results suggest that G6PD-deficient male hemizygotes and female heterozygotes are protected from severe malaria.
Journal ArticleDOI
Asthma and oxidant stress: nutritional, environmental, and genetic risk factors.
TL;DR: Simple dietary and environmental interventions may significantly reduce oxidant stress and prevent or minimize the development of asthmatic symptoms and should prove to be a cost effective approach to asthma management in addition to current pharmacological strategies.
Journal ArticleDOI
G6PD deficiency as protection against falciparum malaria: An epidemiologic critique of population and experimental studies
TL;DR: The evidence indicating that all glucose-6-phosphate dehydrogenase (G6PD) deficient genotypes are relatively pro- tected against Plasmodium falciparum malaria is reviewed.
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