Fatou Sisay-Joof

TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.

TL;DR: This study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

TL;DR: An association study, the first to utilize key molecular genetic variation underlying the ABO system, genotyping >9000 individuals across three African populations demonstrated that alleles producing functional ABO enzymes are associated with greater risk of severe malaria phenotypes in comparison with the frameshift deletion underlying blood group O.

TL;DR: The results suggest that G6PD-deficient male hemizygotes and female heterozygotes are protected from severe malaria.

TL;DR: A range of possible explanations are suggested including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency.