A
Andrew E. Fry
Researcher at University Hospital of Wales
Publications - 63
Citations - 3143
Andrew E. Fry is an academic researcher from University Hospital of Wales. The author has contributed to research in topics: Exome sequencing & Population. The author has an hindex of 25, co-authored 59 publications receiving 2567 citations. Previous affiliations of Andrew E. Fry include Cardiff and Vale University Health Board & Conwy & Denbighshire NHS Trust.
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Journal ArticleDOI
Genome-wide and fine-resolution association analysis of malaria in West Africa
Muminatou Jallow,Yik Ying Teo,Yik Ying Teo,Kerrin S. Small,Kerrin S. Small,Kirk A. Rockett,Kirk A. Rockett,Panos Deloukas,Taane G. Clark,Taane G. Clark,Katja Kivinen,Kalifa Bojang,David J. Conway,Margaret Pinder,Giorgio Sirugo,Fatou Sisay-Joof,Stanley Usen,Sarah Auburn,Sarah Auburn,Suzannah Bumpstead,Susana Campino,Susana Campino,Alison J. Coffey,Andrew Dunham,Andrew E. Fry,Angela Green,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Anna E. Jeffreys,Alieu Mendy,Aarno Palotie,Simon C. Potter,Jiannis Ragoussis,Jane Rogers,Kate Rowlands,Elilan Somaskantharajah,Pamela Whittaker,Claire Widden,Peter Donnelly,Bryan Howie,Jonathan Marchini,Andrew P. Morris,Miguel A. Sanjoaquin,Miguel A. Sanjoaquin,Eric A. Achidi,Tsiri Agbenyega,Angela Allen,Angela Allen,Olukemi K. Amodu,Patrick H. Corran,Abdoulaye A. Djimde,Amagana Dolo,Ogobara K. Doumbo,Chris Drakeley,Sarah J. Dunstan,Jennifer Evans,Jennifer Evans,Jeremy Farrar,Deepika Fernando,Tran Tinh Hien,Rolf D. Horstmann,Muntaser E. Ibrahim,Nadira D. Karunaweera,Gilbert Kokwaro,Kwadwo A. Koram,Martha M. Lemnge,Julie Makani,Kevin Marsh,Pascal Michon,David Modiano,Malcolm E. Molyneux,Ivo Mueller,Michael Parker,Norbert Peshu,Christopher V. Plowe,Odile Puijalon,John C. Reeder,Hugh Reyburn,Eleanor M. Riley,Anavaj Sakuntabhai,Pratap Singhasivanon,Sodiomon B. Sirima,Adama Tall,Terrie E. Taylor,Mahamadou A. Thera,Marita Troye-Blomberg,Thomas N. Williams,Michael T. Wilson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +90 more
TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
Journal ArticleDOI
High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies
Fadi F. Hamdan,Candace T. Myers,Patrick Cossette,Philippe Lemay,Dan Spiegelman,Alexandre D. Laporte,Christina Nassif,Ousmane Diallo,Jean Monlong,Maxime Cadieux-Dion,Maxime Cadieux-Dion,Sylvia Dobrzeniecka,Caroline Meloche,Kyle Retterer,Megan T. Cho,Jill A. Rosenfeld,Weimin Bi,Christine Massicotte,Marguerite Miguet,Ledia Brunga,Brigid M. Regan,Kelly Mo,Cory Tam,Amy L Schneider,Georgie Hollingsworth,David R. FitzPatrick,Alan Donaldson,Natalie Canham,Edward Blair,Bronwyn Kerr,Andrew E. Fry,Rhys H. Thomas,Joss Shelagh,Jane A. Hurst,Helen Brittain,Moira Blyth,Robert Roger Lebel,Erica H. Gerkes,Laura Davis-Keppen,Quinn Stein,Wendy K. Chung,Sara J. Dorison,Paul J. Benke,Emily Fassi,Nicole Corsten-Janssen,Erik-Jan Kamsteeg,Frédéric Tran Mau-Them,Ange-Line Bruel,Alain Verloes,Katrin Õunap,Monica H. Wojcik,Monica H. Wojcik,Dara V.F. Albert,Sunita Venkateswaran,Tyson L Ware,D. L. Jones,Yu Chi Liu,Yu Chi Liu,Shekeeb S. Mohammad,Peyman Bizargity,Carlos A. Bacino,Carlos A. Bacino,Vincenzo Leuzzi,Simone Martinelli,Bruno Dallapiccola,Marco Tartaglia,Lubov Blumkin,Klaas J. Wierenga,Gabriela Purcarin,James J. O'Byrne,Sylvia Stockler,Anna Lehman,Boris Keren,Marie-Christine Nougues,Cyril Mignot,Stéphane Auvin,Caroline Nava,Susan M. Hiatt,Martina Bebin,Yunru Shao,Fernando Scaglia,Seema R. Lalani,Richard E. Frye,Imad Jarjour,Stéphanie Jacques,Renee-Myriam Boucher,Emilie Riou,Myriam Srour,Lionel Carmant,Lionel Carmant,Anne Lortie,Philippe Major,Paola Diadori,François Dubeau,Guy D'Anjou,Guillaume Bourque,Samuel F. Berkovic,Lynette G. Sadleir,Philippe M. Campeau,Philippe M. Campeau,Zoha Kibar,Zoha Kibar,Ronald G. Lafrenière,Simon Girard,Simon Girard,Simon Girard,Saadet Mercimek-Mahmutoglu,Cyrus Boelman,Guy A. Rouleau,Ingrid E. Scheffer,Ingrid E. Scheffer,Ingrid E. Scheffer,Heather C Mefford,Danielle M. Andrade,Elsa Rossignol,Elsa Rossignol,Berge A. Minassian,Berge A. Minassian,Jacques L. Michaud,Jacques L. Michaud +119 more
TL;DR: De novo missense variants explained a larger proportion of individuals in the series than in other series that were primarily ascertained because of ID, indicating that the genetic landscape of DEE might be different from that of ID without epilepsy.
Journal ArticleDOI
De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome
Jean-Baptiste Rivière,Bregje W.M. van Bon,Alexander Hoischen,S.S. Kholmanskikh,Brian J. O'Roak,Christian Gilissen,Sabine Gijsen,Christopher T. Sullivan,Susan L. Christian,Omar A. Abdul-Rahman,Joan F. Atkin,Nicolas Chassaing,Valérie Drouin-Garraud,Andrew E. Fry,Jean-Pierre Fryns,Karen W. Gripp,Marlies Kempers,Tjitske Kleefstra,Grazia M.S. Mancini,Małgorzata J.M. Nowaczyk,Conny M. A. van Ravenswaaij-Arts,Tony Roscioli,Michael Marble,Jill A. Rosenfeld,Victoria Mok Siu,Bert B.A. de Vries,Jay Shendure,Alain Verloes,Joris A. Veltman,Han G. Brunner,M. Elizabeth Ross,Daniela T. Pilz,William B. Dobyns +32 more
TL;DR: The results confirm that trio-based exome sequencing is a powerful approach to discover genes causing sporadic developmental disorders, emphasize the overlapping roles of cytoplasmic actin proteins in development and suggest that Baraitser-Winter syndrome is the predominant phenotype associated with mutation of these two genes.
Journal ArticleDOI
Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
Andrew E. Fry,Michael J. Griffiths,Michael J. Griffiths,Sarah Auburn,Mahamadou Diakite,Julian Forton,Angela Green,Anna Richardson,Jonathan Wilson,Muminatou Jallow,Fatou Sisay-Joof,Margaret Pinder,Norbert Peshu,Thomas N. Williams,Thomas N. Williams,Kevin Marsh,Kevin Marsh,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +22 more
TL;DR: An association study, the first to utilize key molecular genetic variation underlying the ABO system, genotyping >9000 individuals across three African populations demonstrated that alleles producing functional ABO enzymes are associated with greater risk of severe malaria phenotypes in comparison with the frameshift deletion underlying blood group O.
Journal ArticleDOI
How genetically heterogeneous is Kabuki syndrome?: MLL2 testing in 116 patients, review and analyses of mutation and phenotypic spectrum
Siddharth Banka,Ratna Veeramachaneni,William Reardon,Emma Howard,Sancha Bunstone,Nicola Ragge,Michael Parker,Yanick J. Crow,Bronwyn Kerr,Helen Kingston,Kay Metcalfe,Kate Chandler,Alex Magee,Fiona Stewart,Vivienne McConnell,Deirdre E. Donnelly,Siren Berland,Gunnar Houge,Jenny Morton,Christine Oley,Nicole Revencu,Soo Mi Park,Sally J. Davies,Andrew E. Fry,Sally Ann Lynch,Harinder Gill,Susann Schweiger,Wayne W.K. Lam,John Tolmie,Shehla Mohammed,Emma Hobson,Audrey Smith,Moira Blyth,Christopher P. Bennett,Pradeep Vasudevan,Sixto García-Miñaur,Alex Henderson,Judith A. Goodship,Michael Wright,Richard Fisher,Richard Gibbons,Susan Price,Deepthi De Silva,I. Karen Temple,Amanda L. Collins,Katherine Lachlan,Frances Elmslie,Meriel McEntagart,Bruce Castle,Jill Clayton-Smith,Graeme C.M. Black,Dian Donnai +51 more
TL;DR: The largest yet reported cohort of 116 patients with Kabuki syndrome is presented, and the analyses of the phenotype indicates that MLL2 mutation-positive and -negative patients differ systematically, and genetic heterogeneity of KS is not as extensive as previously suggested.