Journal ArticleDOI
Gas chromatography analysis of serum cholesterol synthesis and absorption markers used to predict the efficacy of simvastatin in patients with coronary heart disease
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TLDR
This gas chromatography method should be suitable for the detection of serum squalene and non-cholesterol markers and can be used to predict the efficacy of simvastatin in patients with coronary heart disease.About:
This article is published in Clinical Biochemistry.The article was published on 2013-08-01. It has received 16 citations till now. The article focuses on the topics: Simvastatin & HMG-CoA reductase.read more
Citations
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Journal ArticleDOI
Current Insights into the Biological Action of Squalene
José M. Lou-Bonafonte,José M. Lou-Bonafonte,Roberto Martínez-Beamonte,Roberto Martínez-Beamonte,Teresa Sanclemente,Joaquín C. Surra,Joaquín C. Surra,Luis V. Herrera-Marcos,Javier Sánchez-Marco,Carmen Arnal,Carmen Arnal,Jesús Osada,Jesús Osada +12 more
TL;DR: A systematic review of studies concerning squalene published in the last 8 years has provided further support for its antioxidant, anti-inflammatory, and anti-atherosclerotic properties in vivo and in vitro.
Journal ArticleDOI
Development of a disposable electrochemical sensor for detection of cholesterol using differential pulse voltammetry
Muhammad Azhar Hayat Nawaz,Marjan Majdinasab,Usman Latif,Muhammad Nasir,Gültekin Gökçe,Muhammad Waqas Anwar,Akhtar Hayat +6 more
TL;DR: Under the optimal experimental conditions and using differential pulse voltammetry (DPV) as transduction technique the sensor was able to detect cholesterol level ranges from 1 nM to 3 &mgr;M, with a detection limit of 0.5 nM.
Journal ArticleDOI
Use of targeted exome sequencing in genetic diagnosis of Chinese familial hypercholesterolemia.
TL;DR: Targeted exome sequencing is an effective method for screening mutation genes in familial hypercholesterolemia andSimvastatin plus ezetimibe was proven safe and effective in this preschool-age child and followed up serum lipid levels after treatment.
Journal ArticleDOI
Recovery of palm phytonutrients as a potential market for the by-products generated by palm oil mills and refineries‒A review
TL;DR: A review of the literature on the oil fractions recovered from the by-products generated by the palm oil production chain (OFRB), including the characteristics of the phytonutrients and their concentrations found in various studies, is provided in this article.
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Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?
Tamara Gojkovic,Sandra Vladimirov,Vesna Spasojevic-Kalimanovska,Aleksandra Zeljkovic,Jelena Vekic,Dimitra Kalimanovska-Ostric,Ivana Djuricic,Sladjana Sobajic,Zorana Jelic-Ivanovic +8 more
TL;DR: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis and desmosterol/β-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.
References
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Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Scott M. Grundy,James I. Cleeman,C. Noel Bairey Merz,H. Bryan Brewer,Luther T. Clark,Donald B. Hunninghake,Richard C. Pasternak,Sidney C. Smith,Neil J. Stone +8 more
TL;DR: The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C.
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries Principal results from EUROASPIRE II Euro Heart Survey Programme
David R. Wood,Fulham Palace +1 more
TL;DR: There is considerable potential throughout Europe to raise the standard of preventive cardiology through more effective lifestyle intervention, control of other risk factors and optimal use of prophylactic drug therapies in order to reduce coronary morbidity and mortality.
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Statins for the Primary Prevention of Cardiovascular Events in Women With Elevated High-Sensitivity C-Reactive Protein or Dyslipidemia Results From the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and Meta-Analysis of Women From Primary Prevention Trials
TL;DR: In the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) as discussed by the authors, the authors analyzed sex-specific outcomes in the trial and synthesized the results with prior trials.
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Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment.
TL;DR: Patients with phytosterolemia seem to have a generally increased absorption of sterols rather than a loss of a specific discriminatory mechanism, and oral administration of sitostanol seems to be an interesting new approach for treatment of phytomerolemia.