Journal ArticleDOI
Gastric Absorption and Distribution of Acetylsalicylic Acid and Other Acidic Compounds in the Rat
TLDR
The observations do not rule out the possibility that absorption characteristics of acetylsalicylic acid and its salts may be associated with their ability to cause gastric ulcers.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1970-03-01. It has received 6 citations till now. The article focuses on the topics: Gastric Absorption & Sodium.read more
Citations
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Journal ArticleDOI
Interactions of aspirin with acetaminophen and caffeine in rat stomach: Pharmacokinetics of absorption and accumulation in gastric mucosa
TL;DR: The inhibitory action of acetaminophen and the potentiating action of caffeine on the erosive activity of aspirin are not due to any effects of these drugs on salicylate accumulation in glandular tissue.
Journal ArticleDOI
Comparison of aspirin and copper aspirinate with respect to gastric mucosal damage in the rat
TL;DR: It has been found that Copper aspirinate is at least as damaging as aspirin itself, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa.
Journal ArticleDOI
The metabolism of [carboxyl-14C]aspirin in man.
TL;DR: The major urinary metabolite was salicyluric acid (56-68% dose) and free salicylic and gentisic acids were also detected as were both the acyl and phenolic glucuronides of salricylate as discussed by the authors.
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Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics
TL;DR: This review of the literature represents a comprehensive cross section of the research and development efforts in various selected disciplines of the pharmaceutical sciences.
Journal ArticleDOI
Distribution of Aspirin in Rumen and Corpus Tissues of Rat Stomach during First Four Minutes after Administration
TL;DR: A significant localization of aspirin and/or its metabolites was observed in the submucosa regions of both the rumen and corpus, and the innermost portion of the Rumen mucosa acted as a barrier toward absorption when compared to the corpus mucosa.
References
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Journal ArticleDOI
Accumulation of Drug Anions in Gastric Mucosal Cells
TL;DR: The theory that the absorption of many drugs occurs by the passive diffusion of their non-ionic, lipoid-soluble form has been extended to include transfer across other cell membranes and the effect of pH gradients on the biological distribution of certain drugs has been explained.
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The effect of salicylates upon the stomachs of dogs.
TL;DR: The appearance of the erosions after giving aspirin in solution would indicate that the size of the particles of salicylate is not the important factor in the production of gastric erosion, and may be explained by development of tolerance to the aspirin by the gastric mucosa.
Journal ArticleDOI
Relationship between lesion production, absorption, and distribution of 14C-labeled acetylsalicylic acid
TL;DR: Carbon-14-labeled acetylsalicylic acid in conjunction with liquid scintillation counting and autoradiography was used to study the absorption and localization of the drug in the rat stomach.