Journal ArticleDOI
Generalized muscular stiffness, fasciculations, and myokymia of peripheral nerve origin.
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TLDR
The muscular stiffness and continual EMG activity were abolished by curare but persisted during spinal anesthesia and after peripheral nerve blocks, suggesting that the syndrome was due to isolated, spontaneous, peripheral nerve hyperactivity.Abstract:
THE PERIPHERAL nerve disorders, unlike central nervous system and muscle diseases, have not been widely recognized as causes of generalized muscular stiffness. Isaacs,1,2in 1961 and 1967, reported three patients with an entity of generalized muscular stiffness, fasciculations, continual electromyographic (EMG) activity at rest and depressed deep tendon reflexes. The muscular stiffness and continual EMG activity were abolished by curare but persisted during spinal anesthesia and after peripheral nerve blocks, suggesting that the syndrome was due to isolated, spontaneous, peripheral nerve hyperactivity. Isaacs also discovered that diphenylhydantoin (DPH) induced a substantial and sustained decrease in the muscular stiffness. Similar cases were reported by Mertens and Zschocke3and by Levy et al,4both groups confirming the effects of spinal anesthesia and curare. Mertens and Zschocke3also found carbamazepine as effective as DPH in treatment. Sig wald et al,5Gardner-Medwin and Walton,6and Hughes andread more
Citations
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Journal ArticleDOI
Ectopic generation of impulses and cross-talk in spinal nerve roots of “dystrophic” mice
TL;DR: In “dystrophic” mice, many spinal root axons are bare and closely apposed to one another in midroot, and impulses arise in the spinalRoot axons of dystrophic mice both spontaneously and as a result of cross‐talk between single fibers.
Journal ArticleDOI
Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice.
TL;DR: It is concluded that in at least some cases the direction of ephaptic transmission is from bare axon to myelinated axon, and that there may be multiple sites of spontaneous ectopic excitation in single dystrophic mouse spinal root axons.
Journal ArticleDOI
Hemifacial spasm and the facial nucleus
TL;DR: Spontaneous and associated hyperkinetic facial movements and contracture which follow injury to the seventh cranial nerve or arise without known previous injury (cryptogenic hemifacial spasm) are pathological motor phenomena not found in the distribution of other cranial or somatic motor nerves.
Journal ArticleDOI
Hereditary myokymia and periodic ataxia
TL;DR: The myokymia described here is of interest not only because of its genetic association with a movement disorder, but also because the muscle findings support a peripheral basis for the muscle movements.
Journal ArticleDOI
Hyperexcitability of motor and sensory neurons in neuromyotonia.
TL;DR: Two members of a family with a neuropathy resembling Charcot‐Marie‐Tooth disease were unable to relax their muscles after voluntary contraction, and muscle spasm often outlasted voluntary contraction by 30 seconds or more before subsiding into myokymia and fasciculations.
References
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Journal ArticleDOI
Myokymia with impaired muscular relaxation.
D. Gardner-Medwin,John N. Walton +1 more
TL;DR: The clinical and electromyographic features of myokymia are characteristic and the symptoms can be controlled by treatment with hydantoin derivatives.
Journal ArticleDOI
Pseudo-myotonia and myokymia.
R C Hughes,W B Matthews +1 more
TL;DR: In 1961 Isaacs described the clinical features and effective symptomatic treatment of a previovsly unrecognized form of incapacitating muscular rigidity, but the condition, while distinctive enough, has no accepted name.
Journal ArticleDOI
Effect of some anticonvulsant drugs on the spinal trigeminal nucleus.
TL;DR: It now appears that 10 mg.
Journal ArticleDOI
Myotonia, myokymia, hyperhidrosis, and wasting of muscle
TL;DR: This paper will describe two individuals with some of these symptoms, followed by a review of previously recorded cases and a consideration of the evidence for and against the presence of a definite single entity.
Journal ArticleDOI
Muscle spasm and abnormal postures resulting from damage to interneurones in spinal cord.
TL;DR: A clinical and pathologic study of 3 cases with an abnormal posture in one or more extremities, review other reports, and offer an explanation of the condition.