Stanley van den Noort

TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.

TL;DR: The presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.

TL;DR: B cell-mediated immune response in the cerebrospinal fluid is an early event of inflammatory reaction in the central nervous system of MS, and this procedure also provides a more sensitive method to evaluate the association of humoral immunity in the evolution of MS.

TL;DR: It is reported that a major neurotransmitter, norepinephrine (NE), inhibits, in a dose-response fashion, the ability of gamma-IFN to induce Ia antigen expression on cultured astrocytes derived from newborn BALB/c mice, indicating that the brain contains inhibitory modulators that serve to prevent the up-regulation of intracerebral immune responsiveness.

TL;DR: A case of idiopathic orthostatic hypotension (IOH) is presented with clinical and autopsy data, and electron microscopic examination identifies previously described eosinophil bodies in the sympathetic ganglia as axonal swellings.