Genetic differences in oxygen toxicity are correlated with cytochrome P-450 inducibility.
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TLDR
The difference in responsiveness of mice to microsomal enzyme induction may imply genetic differences in susceptibility to oxidative stress, may help to explain species Differences in susceptibility, and may have long-term implications in therapeutics and patient care if similar inherited differences exist in humans.Citations
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The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
Charlotte Esser,Agneta Rannug +1 more
TL;DR: The role of AhR for immune cells of the barrier organs: skin, gut, and lung is discussed and the current two prevailing views—namely, 1) AhR as a promiscuous sensor for small chemicals and 2) a role for Ahr as a balancing factor for cell differentiation and function, which is controlled by levels of endogenous high-affinity ligands are discussed.
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Oxygen radicals in lung pathology.
Cees J.A. Doelman,Aalt Bast +1 more
TL;DR: Several mechanisms leading to toxicity are described in this review and several antioxidants are discussed which may be beneficial as therapeutics in several lung diseases.
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Developmental aspects of experimental pulmonary oxygen toxicity.
TL;DR: A review of the disparate AOE responses of the neonatal versus adult animal in hyperoxia explores other possible explanations for the striking O2 tolerance of young versus adult animals, including comparative O2 free radical production rates, inflammatory cell responses, lung lipid composition, repair capabilities, etc.
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Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene
Hye-Youn Cho,Anne E. Jedlicka,Sekhar P. Reddy,Liu-Yi Zhang,Thomas W. Kensler,Steven R. Kleeberger +5 more
TL;DR: This study was designed to identify hyperoxia susceptibility genes in C57BL/6J (susceptible) and C3H/HeJ (resistant) mice and identified Nrf2 as a candidate gene.
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Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia.
Carl W. White,Pietro Ghezzi,Charles A. Dinarello,S A Caldwell,Ivan F. McMurtry,John E. Repine +5 more
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