Journal ArticleDOI
Genetic mapping of a murine leukemia virus-inducing locus of AKR mice.
TLDR
The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined, and this identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.Abstract:
The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.read more
Citations
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Journal ArticleDOI
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus.
TL;DR: The results suggest that, in general, viral DNA integration preceded the establishment of inbred mouse strains and that these integrations are relatively stable.
Journal ArticleDOI
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.
TL;DR: Analysis of DNA from a spontaneous DBA/2J d revenant showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
Journal ArticleDOI
Identification and cloning of endogenous retroviral sequences present in human DNA.
TL;DR: The blot-hybridization pattern obtained with cleaved human DNA was similar to that previously reported for the interaction of MuLV cDNA and cleaved mouse DNA and suggested the presence of numerous copies of retrovirus-related sequences in the human genome.
Journal ArticleDOI
Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70.
TL;DR: Results show that control of expression of the MuLV genome in adult and developing mice is linked to differentiation, and the major envelope glycoprotein, gp70, is restricted to certain anatomical sites and cell types.
Journal ArticleDOI
Independent mechanisms involved in suppression of the moloney leukemia virus genome during differentiation of murine teratocarcinoma cells
TL;DR: Two independent mechanisms seem to regulate gene expression during the course of differentiation: the first mechanism operates in undifferentiated cells to block expression of M-MuLV and other exogeneously acquired viral genes, such as SV40 and polyoma virus, and does not depend on DNA methylation.
References
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Journal ArticleDOI
Plaque assay techniques for murine leukemia viruses.
Journal ArticleDOI
Oncogenes of rna tumor viruses as determinants of cancer
TL;DR: An understanding of how normal cells and normal animals prevent expression of endogenous viral information would appear to offer one of the best hopes for the control of naturally occurring cancers.
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Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine
TL;DR: It is indicated that the full genome of murine leukemia virus is present in an unexpressed form in all AKR cells and provide a potentially powerful technique for activating leukemia virus genomes in other cell systems.
Journal ArticleDOI
Induction of Murine C-Type Viruses from Clonal Lines of Virus-Free BALB/3T3 Cells
TL;DR: Each clone of BALB/c mouse embryo cells that has been tested can be induced to form C-type virus, which contains a complete copy of the genetic information for making the murine RNA tumor viruses.
Journal ArticleDOI
Studies of genetic transmission of murine leukemia virus by akr mice. II. Crosses with fv-1b strains of mice.
TL;DR: Evidence is provided that the virus-inducing loci of AKR contain MLV genetic determinants, although the low-virus Fv-1b parents carry the genome of a different host range type.