Genetic Polymorphisms of HO-1 and COX-1 Are Associated With Aspirin Resistance Defined by Light Transmittance Aggregation in Chinese Han Patients
Xiaoli Li,Jian Cao,Li Fan,Qiang Wang,Ling Ye,Chun-Ping Cui,Ya-Zhen Wang,Lin Liu,Bin Li,Ruo-jun Wu,Feng-chun Zhou,Jun-hong Zhang +11 more
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TLDR
The genetic susceptibility of these enzymes to aspirin resistance (AR) is unclear and rs2071746 in HO-1 gene, rs1330344 in COX-1 genes contribute to AR.Abstract:
Background:Cyclooxygenase 1 (COX-1), COX-2, and HO-1 are involved in the process of aspirin’s effect. The genetic susceptibility of these enzymes to aspirin resistance (AR) is unclear. Methods: A t...read more
Citations
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The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: a meta-analysis.
TL;DR: Findings provide strong evidence that COX-2 and ITGA2 genetic defects might increase the risk of having aspirin insensitivity, especially for aspirin semi-resistance and in Chinese populations.
Journal ArticleDOI
Pharmacogenomics of cyclooxygenases.
TL;DR: This work analyses major variations in the PTGS1 and PTGS2 genes, allele frequencies, functional consequences and population genetics, and provides an up-to-date catalog of PTGS clinical associations based on case-control studies and genome-wide association studies, and future research suggestions.
Journal ArticleDOI
Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting.
Xiaoqing Li,Ning Ma,Xingang Li,Bo Wang,Shusen Sun,Feng Gao,Dapeng Mo,Ligang Song,Xuan Sun,Lian Liu,Xingquan Zhao,Yilong Wang,Yongjun Wang,Zhigang Zhao,Zhongrong Miao +14 more
TL;DR: PON1, P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes and testing for these polymorphisms may be valuable in the identification of patients at risk for recurrent ischemic events.
Journal ArticleDOI
Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations.
Pu Song,Kai Li,Ling Liu,Xiaowen Wang,Zhe Jian,Weigang Zhang,Gang Wang,Chunying Li,Tianwen Gao +8 more
TL;DR: Findings indicate that the C allele of rs35652124 located in the promoter region of Nrf2 gene is associated with protective effect on vitiligo in a Han Chinese population.
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TL;DR: The presence of regulatory sequences for the binding of transcription factors such as NF-kappa B and AP-2, whose activation is associated with the immediate response of the cell to an injury, may be an indication of the important role which HO-1 may play in defense mechanisms against tissue injury.
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Association of Laboratory-Defined Aspirin Resistance With a Higher Risk of Recurrent Cardiovascular Events: A Systematic Review and Meta-analysis
Jaapjan D. Snoep,Marcel M. C. Hovens,Jeroen Eikenboom,Johanna G. van der Bom,Menno V. Huisman +4 more
TL;DR: It is shown that patients biochemically identified as having laboratory aspirin resistance are more likely to also have "clinical resistance" to aspirin because they exhibit significantly higher risks of recurrent cardiovascular events compared with patients who are identified as (laboratory) aspirin sensitive.