J
Jeroen Eikenboom
Researcher at Leiden University Medical Center
Publications - 247
Citations - 11491
Jeroen Eikenboom is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Von Willebrand disease & Von Willebrand factor. The author has an hindex of 54, co-authored 228 publications receiving 9984 citations. Previous affiliations of Jeroen Eikenboom include Erasmus University Rotterdam & Erasmus University Medical Center.
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Journal ArticleDOI
Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
J E Sadler,U. Budde,Jeroen Eikenboom,Emmanuel J. Favaloro,Frank Hill,Lars Holmberg,Jørgen Ingerslev,Christine A. Lee,David Lillicrap,P. M. Mannucci,Claudine Mazurier,Dominique Meyer,William L. Nichols,M. Nishino,Ian R. Peake,F. Rodeghiero,Reinhard Schneppenheim,Zaverio M. Ruggeri,A. Srivastava,Robert R. Montgomery,Augusto B. Federici +20 more
TL;DR: Six categories of von Willebrand disease correlate with important clinical features and therapeutic requirements, and certain VWD types, especially type 1 and type 2A, encompass several pathophysiologic mechanisms that sometimes can be distinguished by appropriate laboratory studies.
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A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD)
Alberto Tosetto,Francesco Rodeghiero,Giancarlo Castaman,Anne Goodeve,Augusto B. Federici,Javier Batlle,Dominique Meyer,Edith Fressinaud,Claudine Mazurier,Jenny Goudemand,Jeroen Eikenboom,Reinhard Schneppenheim,U. Budde,Jørgen Ingerslev,Zdena Vorlova,David Habart,Lars Holmberg,Stefan Lethagen,John Pasi,Frank Hill,Ian R. Peake +20 more
TL;DR: Higher BS was related with increasing likelihood of VWD, and a mucocutaneous BS was strongly associated with bleeding after surgery or tooth extraction, which is potentially useful for a more accurate diagnosis of type 1 VWD.
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Association of Laboratory-Defined Aspirin Resistance With a Higher Risk of Recurrent Cardiovascular Events: A Systematic Review and Meta-analysis
Jaapjan D. Snoep,Marcel M. C. Hovens,Jeroen Eikenboom,Johanna G. van der Bom,Menno V. Huisman +4 more
TL;DR: It is shown that patients biochemically identified as having laboratory aspirin resistance are more likely to also have "clinical resistance" to aspirin because they exhibit significantly higher risks of recurrent cardiovascular events compared with patients who are identified as (laboratory) aspirin sensitive.
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Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis.
Jaapjan D. Snoep,Marcel M. C. Hovens,Jeroen Eikenboom,Johanna G. van der Bom,J. Wouter Jukema,Menno V. Huisman +5 more
TL;DR: The results indicate that use of a 600-mg clopidogrel loading dose will reduce these risks, which needs to be confirmed in large prospective studies.
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Phenotype and genotype of a cohort of families historically diagnosed with Type 1 von Willebrand Disease in the European study, molecular and clinical markers for the diagnosis and management of Type 1 von Willebrand Disease (MCMDM-1VWD)
Anne Goodeve,Jeroen Eikenboom,Giancarlo Castaman,Francesco Rodeghiero,Augusto B. Federici,Javier Batlle,Dominique Meyer,Claudine Mazurier,Jenny Goudemand,Reinhard Schneppenheim,Ulrich Budde,Jørgen Ingerslev,David Habart,Zdena Vorlova,Lars Holmberg,Stefan Lethagen,John Pasi,Frank Hill,Mohammad Hashemi Soteh,Luciano Baronciani,Christer Halldén,Andrea Guilliatt,Will Lester,Ian R. Peake +23 more
TL;DR: This study recruited families based on previous type 1 VWD diagnosis and stratified patients into those with or without phenotypes suggestive of qualitative VWF defects (abnormal multimers) and with or with mutations.