Journal ArticleDOI
Glutathione S-transferase M1 and T1 null genotype frequency in chronic myeloid leukaemia.
Bama Charan Mondal,Nandina Paria,Sunipa Majumdar,Sarmila Chandra,Ashis Mukhopadhyay,Utpal Chaudhuri,Uma B. Dasgupta +6 more
TLDR
The GST T1 null genotype frequency in CML patients is significantly different from that in controls (odds ratio (OR) 3.12, 95% confidence interval (CI) 1.3–7.45, P=0.008).Abstract:
Polymorphisms associated with genes coding for glutathione S-transferase enzymes are known to influence metabolism of different carcinogens and have been associated with incidence of various types of cancer. We have determined the GST M1 and GST T1 'null' genotype frequency in 81 patients with chronic myeloid leukaemia (CML) and 123 racially and geographically matched control individuals by multiplex polymerase chain reaction (PCR). GST M1 null genotype frequencies in CML and controls were 28.4% and 27.7%, respectively. GST T1 null genotype frequencies in CML and controls were 19.8% and 7.3%, respectively. The GST T1 null genotype frequency in CML patients is significantly different from that in controls (odds ratio (OR) 3.12, 95% confidence interval (CI) 1.3-7.45, P=0.008).read more
Citations
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Journal ArticleDOI
Glutathione S-transferase polymorphisms: cancer incidence and therapy
TL;DR: This review addresses how differences in the human GST isozyme expression patterns influence cancer susceptibility, prognosis and treatment.
Journal Article
CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.
Mehmet Taspinar,S. Aydos,Omer Comez,Atilla Halil Elhan,Halil Gürhan Karabulut,Asuman Sunguroglu +5 more
TL;DR: Data suggests that polymorphic CYP1A1 and GSTT1 genes appear to affect susceptibility to chronic myeloid leukaemia.
Journal ArticleDOI
Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.
Sunipa Majumdar,Bama Charan Mondal,Moloy Ghosh,Sarmistha Dey,Ashis Mukhopadhyay,Sarmila Chandra,Uma B. Dasgupta +6 more
TL;DR: In the population studied, persons with glutathione-S-transferase M1 null genotype and N-acetyl transferase 2*6B allele are at increased risk of developing AML, and the risk is considerably enhanced in persons with both glutath Pioneer S-transferases M1 and N -acetyltransferase 2 deficiency.
Journal ArticleDOI
Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population.
Graciana Souza Lordelo,Ana Luisa Miranda-Vilela,Arthur K. Akimoto,Penha Cristina Zaidan Alves,C O Hiragi,A Nonino,M B Daldegan,Maria de Nazaré Klautau-Guimarães,Cesar Koppe Grisolia +8 more
TL;DR: A case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTH FR A1298C, del{GSTM1}, del {GSTT1}, and haptoglobin in 105 patients with chronic myeloid leukemia and 273 healthy controls found these two loci to be associated with CML in this population.
Journal ArticleDOI
Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia
TL;DR: It is suggested that heritable GST status may influence the risk of developing CML, and a 2.67-fold increased risk for CML in individuals with GSTT1 null genotype as compared to those possessing both alleles of the gene.
References
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TL;DR: The odds are a way of representing probability, especially familiar for betting, and enable us to examine the effects of other variables on that relationship, using logistic regression.
Journal ArticleDOI
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TL;DR: Recent studies in patients with asthma and cutaneous basal cell carcinoma that demonstrate associations between GSTP1 and GSTT1 genotypes and disease phenotypes indicate the importance of GST polymorphism in determining disease phenotype.
Journal ArticleDOI
Mammalian class theta GST and differential susceptibility to carcinogens: a review.
TL;DR: The comparison of the aminoacidic homologies among mammals suggests that a duplication of an ancient GST theta occurred before the speciation of mammals and resulted in the subunits GSTT1 and GSTT2, which are suspected to confer decreased or increased risk of cancer in relation to the source of exposure.
Journal ArticleDOI
Glutathione S-transferase: genetics and role in toxicology.
TL;DR: In humans, polymorphism in GST genes has been associated with susceptibility to various diseases though some recent data indicate that these genotypes modify disease phenotype, and GST genotypes alone and in combination have been linked with clinical outcome.
Journal Article
The glutathione S-transferases: influence of polymorphism on cancer susceptibility.
TL;DR: The influence of glutathione S-transferase polymorphisms on the risk of several cancers, including basal cell carcinoma of skin, is described, suggesting a role for GST enzymes in the detoxification of the products of ultraviolet radiation-induced oxidative stress.