M
Makoto Murata
Researcher at Nagoya University
Publications - 167
Citations - 3212
Makoto Murata is an academic researcher from Nagoya University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 29, co-authored 157 publications receiving 2702 citations. Previous affiliations of Makoto Murata include University of Washington & Fred Hutchinson Cancer Research Center.
Papers
More filters
Journal ArticleDOI
Target Antigen Density Governs the Efficacy of Anti–CD20-CD28-CD3 ζ Chimeric Antigen Receptor–Modified Effector CD8+ T Cells
Keisuke Watanabe,Seitaro Terakura,Anton C.M. Martens,Tom van Meerten,Susumu Uchiyama,Misa Imai,Reona Sakemura,Tatsunori Goto,Ryo Hanajiri,Nobuhiko Imahashi,Kazuyuki Shimada,Akihiro Tomita,Hitoshi Kiyoi,Tetsuya Nishida,Tomoki Naoe,Makoto Murata +15 more
TL;DR: The threshold target Ag density was determined to be ∼200 molecules per target cell, whereas the Ag density required for cytokine production of CAR-T cells was ∼10-fold higher, at a few thousand pertarget cell.
Journal ArticleDOI
A human minor histocompatibility antigen resulting from differential expression due to a gene deletion
TL;DR: This work has used cDNA expression cloning to identify a novel human minor H antigen encoded by UGT2B17, an autosomal gene in the multigene UDP-glycosyltransferase 2 family that is selectively expressed in liver, intestine, and antigen-presenting cells.
Journal ArticleDOI
A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration
Reona Sakemura,Seitaro Terakura,Keisuke Watanabe,Jakrawadee Julamanee,Erina Takagi,Kotaro Miyao,Daisuke Koyama,Tatsunori Goto,Ryo Hanajiri,Tetsuya Nishida,Makoto Murata,Hitoshi Kiyoi +11 more
TL;DR: An inducible CAR expression strategy was used that controlled CAR expression and shows promise in discriminating between tumor and B-cell expression of CD19, and might open the way to treat other malignancies in combination with other CAR or TCR gene–modified T cells.
Journal ArticleDOI
Biological significance of HLA locus matching in unrelated donor bone marrow transplantation.
Yasuo Morishima,Koichi Kashiwase,Keitaro Matsuo,Fumihiro Azuma,Satoko Morishima,Makoto Onizuka,Toshio Yabe,Makoto Murata,Noriko Doki,Tetsuya Eto,Takehiko Mori,Koichi Miyamura,Hiroshi Sao,Tatsuo Ichinohe,Hiroo Saji,Shunichi Kato,Yoshiko Atsuta,Keisei Kawa,Yoshihisa Kodera,Takehiko Sasazuki +19 more
TL;DR: The biological response to HLA locus mismatch in transplant-related immunologic events is determined, and a rationale for use of a personalized algorithm for unrelated donor selection is provided.
Journal ArticleDOI
Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study
Kazuo Muroi,Koichi Miyamura,Masaya Okada,Takuya Yamashita,Makoto Murata,Takayuki Ishikawa,Naokuni Uike,Michihiro Hidaka,Ryoji Kobayashi,Masahiro Imamura,Junji Tanaka,Kazuteru Ohashi,Shuichi Taniguchi,Takashi Ikeda,Tetsuya Eto,Masaki Mori,Mariko Yamaoka,Keiya Ozawa +17 more
TL;DR: Two clinical trials suggest JR-031 to be effective for steroid-refractory aGVHD and survival was significantly better in patients showing overall response (OR; CR+PR) than in those showing no OR at 4 weeks.