Journal ArticleDOI
Glycogen metabolism in brain and neurons - astrocytes metabolic cooperation can be altered by pre- and neonatal lead (Pb) exposure.
Irena Baranowska-Bosiacka,Anna Falkowska,Izabela Gutowska,Magdalena Gąssowska,Agnieszka Kolasa-Wołosiuk,Maciej Tarnowski,Karina Chibowska,Marta Goschorska,Anna Lubkowska,Dariusz Chlubek +9 more
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TLDR
Exposure to Pb in the pre- and neonatal periods results in a decrease in the level of brain glycogen and a reduction in the rate of its metabolism, thereby reducing glucose availability, which as a further consequence may lead to the impairment of brain energy metabolism and the metabolic cooperation between neurons and astrocytes.About:
This article is published in Toxicology.The article was published on 2017-09-01. It has received 19 citations till now. The article focuses on the topics: Glycogen synthase & Glycogen.read more
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Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity
Daniela Ramírez Ortega,Dinora F. González Esquivel,Tonali Blanco Ayala,Benjamín Pineda,Saul Gómez Manzo,Jaime Marcial Quino,Paul Carrillo Mora,Verónica Pérez de la Cruz +7 more
TL;DR: In this paper, a review aims to provide a general view of the cognitive consequences associated with Pb exposure during early life as well as during adulthood, which includes neurochemical, molecular, and morphological changes that jointly could have a synergic effect on the cognitive performance.
Journal ArticleDOI
Pre- and Neonatal Exposure to Lead (Pb) Induces Neuroinflammation in the Forebrain Cortex, Hippocampus and Cerebellum of Rat Pups.
Karina Chibowska,Jan Korbecki,Izabela Gutowska,Emilia Metryka,Maciej Tarnowski,Marta Goschorska,Katarzyna Barczak,Dariusz Chlubek,Irena Baranowska-Bosiacka +8 more
TL;DR: The effect of exposure of rat pups to Pb during periods of brain development on the concentrations of selected cytokines and prostanoids in the forebrain cortex, hippocampus and cerebellum is analyzed.
Journal ArticleDOI
Lead exposure induces Alzheimers’s disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain
Can-Can Zhou,Zhen-Yan Gao,Ju Wang,Meiqin Wu,Shuang Hu,Fei Chen,Jun-Xia Liu,Hui Pan,Chonghuai Yan +8 more
TL;DR: Developmental lead exposure induced early manifestation of AD-like pathology and disturbed cholesterol metabolism in young rat brains, and the role of cholesterol metabolism was focused on.
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Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.
TL;DR: This review integrates new data on the mechanisms of brain glucose sensing and metabolism including the sweet taste T1R2 + T1R3-mediated brain glucose-sensing and metabolism in brain glucose metabolic disorders.
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Urine metals concentrations and dyslexia among children in China.
Qi Xue,Yu Zhou,Huaiting Gu,Xinyan Xie,Fang Hou,Qi Liu,Hao Wu,Kaiheng Zhu,Zihao Wan,Ranran Song +9 more
TL;DR: It is suggested that exposure to selenium and argentum may relate to dyslexia in China and longitudinal studies are needed to further evaluate these relationships and investigate potential mechanisms.
References
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Journal ArticleDOI
Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter
Richard L. Canfield,Charles R. Henderson,Deborah A. Cory-Slechta,Christopher Cox,Christopher Cox,Todd A. Jusko,Bruce P. Lanphear +6 more
TL;DR: Blood lead concentrations, even those below 10 microg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations.
Journal ArticleDOI
Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
TL;DR: The physiological role of gap junctions in several tissues has been elucidated by the discovery of mutant connexins associated with genetic diseases and by the generation of mice with targeted ablation of specific connexin genes.
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From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment.
Bita Moghaddam,Daniel C. Javitt +1 more
TL;DR: NMDAR has intrinsic modulatory sites that are active targets for drug development, several of which show promise in preclinical/early clinical trials targeting both symptoms and cognition, and allosteric modulators, both positive and negative, may offer superior efficacy with less danger of downregulation.
Journal ArticleDOI
The selenoprotein gpx4 is essential for mouse development and protects from radiation and oxidative damage insults
Levi Yant,Qitao Ran,Lin Rao,Holly Van Remmen,Toru Shibatani,Jason G. Belter,Lucia Motta,Arlan Richardson,Tomas A. Prolla +8 more
TL;DR: The generation and characterization of GPX4-deficient mice are described by targeted disruption of the murine Gpx4 locus through homologous recombination in embryonic stem cells and it is suggested that it performs broad functions as a component of the mammalian antioxidant network.
Journal ArticleDOI
Blood Lead Concentrations < 10 μg/dL and Child Intelligence at 6 Years of Age
Todd A. Jusko,Charles Henderson,Bruce P. Lanphear,Deborah A. Cory-Slechta,Patrick J. Parsons,Richard L. Canfield +5 more
TL;DR: Weitzman et al. as mentioned in this paper found that the overall weight of evidence supports an inverse association between blood lead levels < 10 μg/dL and the cognitive function of children, with the caveat that the available data were limited by the small number of directly relevant cohort studies.