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Qitao Ran
Researcher at University of Texas Health Science Center at San Antonio
Publications - 50
Citations - 8232
Qitao Ran is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: GPX4 & Oxidative stress. The author has an hindex of 27, co-authored 43 publications receiving 5329 citations. Previous affiliations of Qitao Ran include University of Texas at San Antonio & United States Department of Veterans Affairs.
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Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
Journal ArticleDOI
The selenoprotein gpx4 is essential for mouse development and protects from radiation and oxidative damage insults
Levi Yant,Qitao Ran,Lin Rao,Holly Van Remmen,Toru Shibatani,Jason G. Belter,Lucia Motta,Arlan Richardson,Tomas A. Prolla +8 more
TL;DR: The generation and characterization of GPX4-deficient mice are described by targeted disruption of the murine Gpx4 locus through homologous recombination in embryonic stem cells and it is suggested that it performs broad functions as a component of the mammalian antioxidant network.
Journal ArticleDOI
Is the oxidative stress theory of aging dead
Viviana I. Pérez,Alex Bokov,Holly Van Remmen,James Mele,Qitao Ran,Yuji Ikeno,Arlan Richardson +6 more
TL;DR: Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations studied had an effect on lifespan, the hypothesis that alterations in oxidative damage/stress play a role in the longevity of mice is called into serious question.
Journal ArticleDOI
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration.
TL;DR: Results indicate that forebrain neurons are susceptible to ferroptosis, suggesting that ferroPTosis may be an important neurodegenerative mechanism in diseases such as AD.
Journal ArticleDOI
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
Rui Kang,Ling Zeng,Shan Zhu,Yangchun Xie,Jiao Liu,Qirong Wen,Lizhi Cao,Min Xie,Qitao Ran,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Daolin Tang +14 more
TL;DR: It is suggested that lipid peroxidation drives GSDMD-mediated pyroptosis and hence constitutes a potential therapeutic target for lethal infection.