Journal ArticleDOI
Growth-differentiation factor-15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors.
Derya Arslan,Tugba Cihan,Doğan Köse,Husamettin Vatansev,Derya Çimen,Yavuz Köksal,Bülent Oran,Fikret Akyurek +7 more
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TLDR
GDF-15 level may be used as a biomarker of anthracycline-induced cardiovascular disease severity in the CCS and there were significant differences between parameters of diastolic function of the heart.About:
This article is published in Clinical Biochemistry.The article was published on 2013-09-01. It has received 19 citations till now. The article focuses on the topics: Cardiomyopathy & Asymptomatic.read more
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Journal ArticleDOI
Role of Biomarkers in Prediction of Cardiotoxicity During Cancer Treatment
Li-Ling Tan,Alexander R. Lyon +1 more
TL;DR: Although biomarkers are an attractive option in the detection of cardiotoxicity among cancer patients, current recommendations surrounding its role are based on expert consensus opinion and further research is required to guide optimal clinical practice.
Journal ArticleDOI
Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells.
Gustav Holmgren,Jane Synnergren,Yalda Bogestål,Caroline Améen,Karolina Åkesson,Sandra Holmgren,Anders Lindahl,Peter Sartipy +7 more
TL;DR: The results from this study show that cTnT release can be used as a measurement of acute cardiotoxicity due to doxorubicin, however, for the late onset of doxorbicin-induced cardiomyopathy, cTNT release might not be the most optimal biomarker.
Journal ArticleDOI
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates.
Danna M. Breen,Hanna Kim,Donald Bennett,Roberto A. Calle,Susie Collins,Ryan M. Esquejo,Tao He,Stephanie Joaquim,Alison Joyce,Matthew Allister Lambert,Laura Lin,Betty Pettersen,Shuxi Qiao,Michelle Rossulek,Gregory Weber,Zhidan Wu,Bei B. Zhang,Morris J. Birnbaum +17 more
TL;DR: It is found that circulating GDF-15 is higher in subjects with cancer receiving platinum-based chemotherapy and is positively associated with weight loss in colorectal cancer and that mAB1 treatment attenuates anorexia and emesis in nonhuman primates.
Journal ArticleDOI
Cardiotoxicity of anthracycline therapy: current perspectives.
TL;DR: According to previous clinical trials, the major high-risk factors for anthracycline-induced cardiotoxicity are age, body weight, female gender, radiotherapy, and other diseases such as Down syndrome, familial dilated cardiomyopathy, diabetes and hypertension.
Journal ArticleDOI
Protecting the heart in cancer therapy.
TL;DR: This work defines cancer therapeutics-induced cardiotoxicity as the direct or indirect cardiovascular injury or injurious effect caused by cancer therapies, and describes four progressive stages of this condition and four corresponding levels of prevention.
References
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Recommendations for chamber quantification
Roberto M. Lang,Michelle Bierig,Richard B. Devereux,Frank A. Flachskampf,Elyse Foster,Patricia A. Pellikka,Michael H. Picard,Mary J. Roman,James D. Seward,Jack S. Shanewise,Scott Robert Solomon,Kirk T. Spencer,Martin St John Sutton,William W. Stewart +13 more
TL;DR: This document reviews the technical aspects on how to perform quantitative chamber measurements of morphology and function, which is a component of every complete echocardiographic examination.
Book ChapterDOI
Avian Clinical Biochemistry
TL;DR: This chapter begins with discussing how blood samples of birds can be collected in the most efficient way and elaborates the biochemistry of plasma proteins, renal function, and hepatobiliary disease in birds.
Journal ArticleDOI
Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century
Malcolm A. Smith,Nita L. Seibel,Sean F. Altekruse,Lynn A. G. Ries,Danielle L. Melbert,Maura O'Leary,Franklin O. Smith,Gregory H. Reaman +7 more
TL;DR: Almost 38,000 childhood malignant cancer deaths were averted in the United States from 1975 through 2006 as a result of more effective treatments identified and applied during this period.
Journal ArticleDOI
Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition
Daniela Cardinale,Alessandro Colombo,Maria T. Sandri,Giuseppina Lamantia,Nicola Colombo,Maurizio Civelli,Giovanni Martinelli,Fabrizio Veglia,Cesare Fiorentini,Carlo M. Cipolla +9 more
TL;DR: In high-risk, HDC-treated patients, defined by an increased troponin I value, early treatment with enalapril seems to prevent the development of late cardiotoxicity.
Journal ArticleDOI
Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy
Daniela Cardinale,Maria T. Sandri,Alessandro Colombo,Nicola Colombo,Marina Boeri,Giuseppina Lamantia,Maurizio Civelli,Fedro A. Peccatori,Giovanni Martinelli,Cesare Fiorentini,Carlo M. Cipolla +10 more
TL;DR: TnI release pattern after high-dose chemotherapy identifies patients at different risks of cardiac events in the 3 years thereafter, and stratification allows the monitoring program and to plan, in selected patients, preventive strategies aimed at improving clinical outcome.
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Bonnie Ky,Mary E. Putt,Heloisa Sawaya,Benjamin French,James L. Januzzi,Igal A. Sebag,Juan Carlos Plana,Victor Cohen,Jose Banchs,Joseph R. Carver,Susan E. Wiegers,Randolph P. Martin,Michael H. Picard,Robert E. Gerszten,Elkan F. Halpern,Jonathan J. Passeri,Irene Kuter,Marielle Scherrer-Crosbie +17 more