Journal ArticleDOI
Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas
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This article is published in Journal of the National Cancer Institute.The article was published on 1971-01-01. It has received 643 citations till now. The article focuses on the topics: Tissue culture.read more
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The third dimension bridges the gap between cell culture and live tissue
TL;DR: It is believed that 3D cultures will have a strong impact on drug screening and will also decrease the use of laboratory animals, for example, in the context of toxicity assays.
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Cell and environment interactions in tumor microregions: the multicell spheroid model
TL;DR: The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.
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In vitro cell migration and invasion assays.
Nina Kramer,Angelika Walzl,Christine Unger,Margit Rosner,Georg Krupitza,Markus Hengstschläger,Helmut Dolznig +6 more
TL;DR: A concise summary of established migration/invasion assays described in the literature is provided, list advantages, limitations and drawbacks, give a tabular overview for convenience and depict the basic principles of the assays graphically.
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Spherical cancer models in tumor biology.
Louis Bastien Weiswald,Dominique Bellet,Dominique Bellet,Virginie Dangles-Marie,Virginie Dangles-Marie +4 more
TL;DR: The four most commonly used spherical cancer models in cancer research are proposed based on culture methods for obtaining them and on subsequent differences in sphere biology: the multicellular tumor spheroid model, first described in the early 70s and obtained by culture of cancer cell lines under nonadherent conditions; tumorospheres, a model of cancer stem cell expansion established in a serum-free medium supplemented with growth factors.