Headache and Epilepsy.
Dong Wook Kim,Sang Kun Lee +1 more
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TLDR
The connection between headache and epilepsy in various aspects is discussed, including classification, clinical features, epidemiology, genetics, pathophysiology, and treatment.Abstract:
Headache, especially migraine, has long been associated with epilepsy, based on the common clinical features of these disorders. Both migraine and epilepsy have a genetic predisposition and share common pathophysiological mechanisms including an imbalance between excitatory and inhibitory factors that result in spells of altered brain function and autonomic symptoms. There are well-documented reports on the headache as a sole manifestation of epileptic seizure and headache is commonly associated with as preictal, ictal, and postictal symptoms in epilepsy patients. In addition, migraine and epilepsy are frequently described as highly comorbid conditions and several antiepileptic drugs are used for the patients with migraine as well as epilepsy. In the present review, we briefly discuss the connection between headache and epilepsy in various aspects, including classification, clinical features, epidemiology, genetics, pathophysiology, and treatment.read more
Citations
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Journal ArticleDOI
Headache in epilepsy: prevalence and clinical features
Greta Mainieri,Greta Mainieri,S. Cevoli,Giulia Giannini,Giulia Giannini,L. Zummo,L. Zummo,L. Zummo,Chiara Leta,Chiara Leta,M. Broli,M. Broli,Lorenzo Ferri,Lorenzo Ferri,Margherita Santucci,Margherita Santucci,Annio Posar,Annio Posar,Patrizia Avoni,Patrizia Avoni,Pietro Cortelli,Pietro Cortelli,Paolo Tinuper,Paolo Tinuper,Francesca Bisulli,Francesca Bisulli +25 more
TL;DR: Migraine was the most represented type of headache in patients with epilepsy, while patients with any inter-IH (migraine or TTH) are predisposed to manifest a post- IH after seizures.
Journal ArticleDOI
The comorbid relationship between migraine and epilepsy: a systematic review and meta‐analysis
TL;DR: Subgroup analyses revealed that the method of ascertaining the epilepsy or migraine status of subjects was an important source of inter‐study heterogeneity, and additional high quality primary studies are required.
Journal ArticleDOI
The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis
TL;DR: The pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%) and Screening and appropriate management of headaches among Patients with epilepsy are warranted.
Journal ArticleDOI
Headache as an Aura of Epilepsy: Video-EEG Monitoring Study.
TL;DR: Investigation of the incidence and characteristics of headache as an epileptic aura via confirmation of electroencephalography (EEG) changes by video‐EEG monitoring.
Journal ArticleDOI
Novel Therapeutic Targets Against Spreading Depression
Shih Pin Chen,Cenk Ayata +1 more
TL;DR: An overview of novel therapeutic targets that show promise to suppress Cortical spreading depression is provided, such as acid‐sensing ion channels, casein kinase Iδ, P2X7‐pannexin 1 complex, and neuromodulation.
References
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Journal ArticleDOI
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