Journal ArticleDOI
Helicobacter pylori FliD protein is a highly sensitive and specific marker for serologic diagnosis of H. pylori infection.
Mohammad Khalifeh Gholi,Behnam Kalali,Luca Formichella,Gereon Göttner,Fereshteh Shamsipour,Amir-Hassan Zarnani,Amir-Hassan Zarnani,Mostafa Hosseini,Dirk H. Busch,M H Shirazi,Markus Gerhard +10 more
TLDR
This work identified the H. pylori "hook-associated protein 2 homologue", FliD (UniProtKB/Swiss-Prot: P96786) as a novel marker of infection for serological analysis and screened a defined panel of patient sera to evaluate its antigenicity, finding it to have a high specificity of up to 99% and a sensitivity up to 97%.About:
This article is published in International Journal of Medical Microbiology.The article was published on 2013-12-01. It has received 42 citations till now. The article focuses on the topics: Population.read more
Citations
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Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis
TL;DR: A review highlights the key findings of H. pylori virulence factors reported over the past 20 years and the development of large-scale screening methods, including proteomic, and transcriptomic tools, has been used to determine the complex gene regulatory networks in the bacterium.
Journal ArticleDOI
Diagnosis of Helicobacter pylori infection: Current options and developments
Yao-Kuang Wang,Fu-Chen Kuo,Chung-Jung Liu,Meng-Chieh Wu,Hsiang-Yao Shih,Sophie Wang,Jeng-Yih Wu,Chao-Hung Kuo,Yao-Kang Huang,Deng-Chyang Wu +9 more
TL;DR: The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes.
Journal ArticleDOI
Non-invasive diagnostic tests for Helicobacter pylori infection
Lawrence M.J. Best,Yemisi Takwoingi,Sulman Siddique,Abiram Selladurai,Akash Gandhi,Benjamin Low,Mohammad Yaghoobi,Kurinchi Selvan Gurusamy +7 more
TL;DR: To compare the diagnostic accuracy of urea breath test, serology, and stool antigen test, used alone or in combination, for diagnosis of H pylori infection in symptomatic and asymptomatic people, a meta-analysis was performed by using the hierarchical summary receiver operating characteristic (HSROC) model.
Journal ArticleDOI
Pathogenesis and clinical management of Helicobacter pylori gastric infection.
Breno Bittencourt de Brito,Filipe Antônio França da Silva,Aline Silva Soares,Vinícius Afonso Pereira,Maria Luísa Cordeiro Santos,Mariana Miranda Sampaio,Pedro Henrique Moreira Neves,Fabrício Freire de Melo +7 more
TL;DR: The infection can be acquired by means of oral-oral or fecal-oral transmission, and the pathogen possesses various mechanisms that improve its capacity of mobility, adherence and manipulation of the gastric microenvironment, making possible the colonization of an organ with a highly acidic lumen.
Journal ArticleDOI
Helicobacter pylori infection- recent developments in diagnosis
TL;DR: This review concerns the contribution of novel endoscopic evaluation methodologies for the diagnosis of H. pylori infection, such as magnifying endoscopy techniques and chromoendoscopy, and the diagnostic contribution of histology and the urea breath test.
References
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Journal ArticleDOI
Helicobacter pylori infection and the development of gastric cancer
Naomi Uemura,Sumika Okamoto,Susumu Yamamoto,Nobuyuki Matsumura,Shigeki Yamaguchi,Michio Yamakido,Kiyomi Taniyama,Noboyuki Sasaki,Ronald J Schlemper +8 more
TL;DR: Gastric cancer develops in persons infected with H. pylori but not in uninfected persons, and those with histologic findings of severe gastric atrophy, corpus-predominant gastritis, or intestinal metaplasia are at increased risk.
Journal ArticleDOI
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori ASSOCIATION OF SPECIFIC vacA TYPES WITH CYTOTOXIN PRODUCTION AND PEPTIC ULCERATION
John Atherton,Ping Cao,Richard M. Peek,Murali K. R. Tummuru,Martin J. Blaser,Timothy L. Cover +5 more
TL;DR: Specific vacA genotypes of H. pylori strains are associated with the level of in vitro cytotoxin activity as well as clinical consequences, which implies that recombination has occurred in vivo between vacA alleles.
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Helicobacter pylori Infection Induces Gastric Cancer in Mongolian Gerbils
TL;DR: It is successfully demonstrated that long-term infection with H. pylori induces adenocarcinoma in Mongolian gerbils, and the observations are highly suggestive of the involvement of H.pylori infection in gastric carcinogenesis in humans.
Journal ArticleDOI
Purification and characterization of the vacuolating toxin from Helicobacter pylori.
TL;DR: A vacuolating toxin was purified to homogeneity from broth culture supernatant of the human gastric bacterium, Helicobacter pylori, and recognition of the purified M(r) = 87,000 protein by human sera was significantly associated with toxin-neutralizing activity.
Journal ArticleDOI
Activation of β-catenin by carcinogenic Helicobacter pylori
Aime T. Franco,Dawn A. Israel,Mary Kay Washington,Uma Krishna,James G. Fox,Arlin B. Rogers,Andrew S. Neish,Lauren S. Collier-Hyams,Guillermo I. Perez-Perez,Masanori Hatakeyama,Robert H. Whitehead,Kristin Gaus,Daniel O'Brien,Judith Romero-Gallo,Richard M. Peek +14 more
TL;DR: In vivo adaptation endowed an H. pylori strain with the ability to rapidly and reproducibly induce gastric dysplasia and adenocarcinoma in a rodent model of gastritis, indicating that H.pylori-induced dysregulation of β-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen.