Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka.
Pamoda B. Ratnaweera,David E. Williams,E. Dilip de Silva,Ravi L. C. Wijesundera,Doralyn S. Dalisay,Raymond J. Andersen +5 more
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An endophytic fungus isolated from surface sterilized leaf segments of Anoectochilus setaceus, an orchid endemic to Sri Lanka, and was identified as Xylaria sp.Abstract:
An endophytic fungus was isolated from surface sterilized leaf segments of Anoectochilus setaceus, an orchid endemic to Sri Lanka, and was identified as Xylaria sp. by morphological characters and DNA sequencing. Bioassay-guided chromatographic fractionation of the organic extract of a laboratory culture of this fungus led to the isolation of the known antibacterial helvolic acid. Helvolic acid was active against the Gram-positive bacteria, Bacillus subtilis [minimal inhibitory concentrations (MIC), 2 μg mL−1] and methicillin-resistant Staphylococcus aureus (MIC, 4 μg mL−1).read more
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Journal ArticleDOI
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Journal ArticleDOI
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TL;DR: In this paper, the authors investigated the role of the endophyte and its biologically active metabolites in its association with its host and found that a higher proportion of the fungal endophytes, in contrast to the soil isolates, inhibited at least one of the test organisms for antialgal and herbicidal activities.