Journal ArticleDOI
Hemosiderosis in refractory anemia.
J. P. Wyatt,H. Goldenberg +1 more
TLDR
A dramatic observation in cases of refractory anemia treated with multiple blood transfusions has been the development of hemosiderosis of the liver, spleen and other organs.Abstract:
THE DISCOVERY of iron and liver therapy has brought into prominence a type of primary anemia which fails to respond to any known treatment. This type has therefore been referred to as primary refractory anemia by Bomford and Rhoads, 1 who have further subdivided it into four types according to the histopathologic appearance of the bone marrow. These, with their clinically comparable conditions, are pseudoplastic anemia (partly mature, cellular marrow), aplastic anemia, or panmyelophthisis (hypocellular marrow), chronic granulocytopenia (immature cellular marrow) and myelosclerosis (fibrosis, sclerosis, and giant cell hyperplasia of the marrow). With the lack of specific therapy, the main source of treatment is repeated blood transfusions. A dramatic observation in cases of refractory anemia treated with multiple blood transfusions has been the development of hemosiderosis of the liver, spleen and other organs. An analysis of autopsy observations in 20 cases of refractory anemia from Bomford and Rhoad's series revealedread more
Citations
More filters
Journal ArticleDOI
The physiologic evaluation and management of chronic bone marrow failure.
TL;DR: Evidence is presented to suggest that it is these patients who are most likely to respond favorably to splenectomy, and the anemia of chronic bone marrow failure should not be considered entirely refractory to therapy.
Journal ArticleDOI
Aplastic anemia: an analysis of 50 cases
Daniel N. Mohler,Byrd S. Leavell +1 more
TL;DR: This paper presents a new type of anemia called aplastic anemia, which has shown marked characteristics of both bone marrow failure and “generative” anemia.
Journal ArticleDOI
Transfusional siderosis: the effects of excessive iron deposits on the tissues.
Journal ArticleDOI
The Relation of Portal Cirrhosis to Hemochromatosis and to Diabetes Mellitus
TL;DR: This study is based upon 932 cases of clinical portal cirrhosis from the autopsy service at the University of Minnesota, and it includes all the cases of this disease recorded during the forty-four year period 1911 through 1953.
Journal ArticleDOI
Refractory anemia with hyperplastic bone marrow.
Richard W. Vilter,Thomas Jarrold,John J. Will,John F. Mueller,Ben I. Friedman,Virginia R. Hawkins +5 more
TL;DR: Five types of anemia are separated into five types on the basis of clinical and hematologic studies on 23 patients carried out over a period of 16 years, and Hypotheses are proposed to explain these various types ofAnemia on the based of abnormalities in the metabolism of nucleic acids, particularly DNA.
References
More filters
Journal ArticleDOI
Agnogenic Myeloid Metaplasia of the Spleen
Journal ArticleDOI
Refractory anaemiai. clinical and pathological aspects
R. R. Bomford,C. P. Rhoads +1 more
Journal ArticleDOI
Aplastic anemia and its association with hemochromatosis
Kurt Zeltmacher,Margaret Bevans +1 more
TL;DR: The purpose of this paper is to draw further attention to this association between hemochromatosis and aplastic anemia by reviewing the reported cases, adding another case and discussing the pathologic changes common to the two conditions.
Journal ArticleDOI
Treatment of pernicious anemia
TL;DR: It is now well established that one-half pound (0.2 Kg.) of liver taken as part of the daily diet will cause an increase in the number of new red blood cells in the circulation.