Journal ArticleDOI
Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules.
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It is concluded that conjugation of Nap to HSA itself results in a selective delivery to endothelial cells and that the local proteolysis of the conjugate produces an active catabolite.About:
This article is published in Biochemical Pharmacology.The article was published on 1993-03-24. It has received 54 citations till now. The article focuses on the topics: Nap & Human serum albumin.read more
Citations
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Journal ArticleDOI
Glycoprotein synthesis: an update.
TL;DR: Glycoprotein Remodeling (GPR) 152, Enzymatic Formation of the Glycan-Protein/ Peptide Link 153, and enzymatics in Glycan Extension 4.2.1.
Journal ArticleDOI
Synthesis of glycoproteins.
TL;DR: The remarkable diversity of techniques available for the construction of glycoproteins is presented and it is unlikely to be enough to "just make it", and in this regard the timing of glycosylation and assembly strategy in any synthesis may too become a vital issue.
Journal ArticleDOI
Asialoglycoprotein receptor mediated hepatocyte targeting - strategies and applications.
TL;DR: Various ligands and nanocarriers exploited for ASGPR mediated delivery of drugs to hepatocytes provide great promise for improved therapy of hepatic afflictions and applications in diagnostics are highlighted.
Journal ArticleDOI
Supramolecular chemistry of cyclodextrins in enzyme technology.
TL;DR: The most recent applications of CDs in the biotechnological field are focused on, including application of NMR spectroscopy, computational chemistry, and X-ray crystallographys among other techniquess for the elucidation of the structures of CDs and their complexes.
Journal Article
Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression.
Xiaoyuan Chen,Yingping Hou,Michel Tohme,Ryan Park,Vazgen Khankaldyyan,Ignacio Gonzales-Gomez,James R. Bading,Walter E. Laug,Peter S. Conti +8 more
TL;DR: The radiotracer was synthesized with a high specific activity and the c(RGDyK)-PEG-DOTA ligand showed intermediate binding affinity for alphavbeta3-integrin, and this tracer showed improved in vivo kinetics, with significantly reduced liver uptake.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
Book
Clinical Pharmacokinetics: Concepts and Applications
Malcolm Rowland,Thomas N. Tozer +1 more
TL;DR: The Third Edition of Clinical Pharmacokinetics features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed.
Journal ArticleDOI
Determination of free amino groups in proteins by trinitrobenzenesulfonic acid
TL;DR: A sensitive method to determine the free amino groups in proteins is presented that makes use of the reagent 2,4,6-trinitrobenzenesulfonic acid and found that sodium dodecyl sulfate was bound to some of the ϵ-amino groups of lysine in bovine serum albumin, ovalbumin, and human γ-globulin and rendered the involved amino groups unreactive toward TNBS.