Hepatic GABAA receptor functional regulation during rat liver cell proliferation
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TLDR
The results suggest that GABA(A) receptor act as an inhibitory signal for hepatic cell proliferation and enhanced the transforming growth factor beta1 (TGFbeta1) mediated DNA synthesis suppression in primary hepatocyte cultures.About:
This article is published in Hepatology Research.The article was published on 2001-10-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: GABAA receptor & GABA receptor.read more
Citations
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Journal ArticleDOI
GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches.
TL;DR: GABA's presence as a near-universal signal that may be altered in tumor cells resulting in modified mitotic activity is discussed.
Journal ArticleDOI
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Anna Kinoshita,Hideki Wanibuchi,Keiichirou Morimura,Min Wei,Jun Shen,Susumu Imaoka,Yoshihiko Funae,Shoji Fukushima +7 more
TL;DR: Results indicate that phenobarbital exhibits hormetic effect on rat hepatocarcinogenesis initiated with DEN by differentially altering cell proliferation, apoptosis and oxidative DNA damage at high and low doses.
Journal ArticleDOI
Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats.
TL;DR: The studies suggest that curcumin plays a vital role in regulating the activity of cholinergic and insulin receptors and mechanism of glucose transportation through Glut3, which results in normalizing the diabetes-mediated cerebellar disorders.
Journal ArticleDOI
Increased Insulin Secretion by Muscarinic M1 and M3 Receptor Function from Rat Pancreatic Islets in vitro
TL;DR: The studies suggest that muscarinic M1 and M3 receptors function differentially regulate glucose induced insulin secretion, which has clinical significance in glucose homeostasis.
Journal ArticleDOI
Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: functional regulation with Vitamin D3 supplementation.
TL;DR: Vitamin D3 functional regulation through dopaminergic, cholinergic and insulin receptors and glucose transport mechanism through GLUT3 in the cerebellum of diabetic rats which play a major role in neuroprotection in diabetes which has clinical application is showed.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
Book ChapterDOI
Preparation of isolated rat liver cells.
TL;DR: This chapter discusses preparation of isolated rat liver cells by incubation of rat liver minces with pronase, which results in most of the liver parenchyma is digested, while nonparenchymal cells remain intact and can be recovered from the incubate.