Showing papers in "Life Sciences in 2009"

TL;DR: The purpose of this review is to discuss the role of oxidative stress in metabolic syndrome and its major clinical manifestations (namely coronary artery disease, hypertension and diabetes), and to highlight the effects of lifestyle modification in ameliorating oxidative stress.

TL;DR: Perinatal exposure to environmentally relevant doses of BPA affects the male germ line, leading to impairments in the fertility of F(1) male offspring and their subsequent F(2) and F(3) generations.

TL;DR: The different effects of cytokines on TNAP activity and collagen expression may help explain why inflammation decreases bone formation in RA whereas it induces ectopic ossification from collagen-rich entheses during SpAs.

TL;DR: The data reveal that tocotrienol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation and apoptosis and thus exerts a marked renoprotective effect.

TL;DR: Melatonin receptors constitute attractive targets for developing analgesic drugs, and their activation may prove to be a useful strategy to generate analgesics with a novel mechanism of action.

TL;DR: The results suggest that HT22 cells possess functional cholinergic properties, and can be used for an in vitro model for defining the mechanisms in cognitive deficits of Alzheimer's disease.

TL;DR: The data suggest that chamomile works by a mechanism of action similar to that attributed to non-steroidal anti-inflammatory drugs, including sulindac and a specific COX-2 inhibitor, NS398, that act similarly in LPS-activated RAW 264.7 cells.

TL;DR: The ability of kolaviron to inhibit COX-2 and iNOS expression through down regulation of NF-kappaB and AP-1 DNA binding activities could be a mechanism for the hepatoprotective properties of k Kolaviron.

TL;DR: It is suggested that caffeic acid protected the PC12 cells against Abeta-induced toxicity by attenuating the elevation of intracellular calcium levels and tau phosphorylation and the reduction of GSK-3beta activation.

TL;DR: Results show that TQ at 80mg/kg b.w is associated with beneficial changes in hepatic enzyme activities and thereby exerts potential antihyperglycemic effects in STZ-NA induced diabetic rats.

TL;DR: NPQC prevented the arsenite-induced reduction in antioxidant levels in the liver and brain, and NPQC treatment resulted in a unique protection against the loss.

TL;DR: The results revealed that SM22 alpha directly interacted and colocalized with F-actin and thus participated in the organization of the actin cytoskeleton in differentiated VSMCs and is necessary for maintaining the differentiated phenotype ofVSMCs.

TL;DR: Perinatal exposure of male rats to BPA leads to transgenerational perturbations in the expression profile of testicular steroid receptor coregulators in the F(1) generation.

TL;DR: Findings indicate that both caspase-dependent and casp enzyme-independent mechanisms are involved in coordinating the activation of apoptosis induced by H(2)O( 2) in differentiated myotubes.

TL;DR: The administration of daidzein in vivo attenuates I/R-induced myocardial damage via inhibition of NF-kappaB activation, which in turn may suppress inflammatory cytokine expression.

TL;DR: The results suggest that magnolol could improve insulin sensitivity through the activation of PPARgamma as a ligand.

TL;DR: The data suggest that hBMMSCs may facilitate recovery from chronic liver damage and may decrease liver fibrosis, and are a potential option for treatment of liver cirrhosis.

TL;DR: H2S significantly protected PC12 cells against cytotoxicity and apoptosis induced by MPP (+), which was associated with the inhibition by H(2)S of MPP(+)-induced dissipation of MMP and overproduction of ROS.

TL;DR: Low vagal nerve activity and increased sympathetic nerve activity are associated with central nervous system fatigue and electrocardiographic R-R wave interval analyses showed a decreased high- frequencies component power and an increasing trend in the low-frequency component power/high-frequency components power ratio.

TL;DR: EGCG is proposed as potential inhibitor of expression and activity of pro-MMP-2 by a process involving multiple regulatory molecules in human breast cancer cell line, MCF-7.

TL;DR: The studies suggest that N-acetylcysteine has antioxidative and antiapoptotic activity against G/GO-induced oxidative stress through the inhibition of mitochondrial damage in H9c2 cells.

TL;DR: THSG exerts its stimulatory effect on melanogenesis by MAP kinase activation and MITF-induction of tyrosinase, suggesting that THSG-mediated MITF activation may be cAMP dependent.

TL;DR: This work investigated the mechanisms underlying the dysregulation by resistin of these regulators leading to promotion of lipid accumulation in bone marrow-derived macrophages, and found that SR-A and CD36 are transcriptionally up-regulated by resistsin through AP-1 and PPARgamma, respectively, whereas ABCA1 is down-regulatedby resistin through proteasome-mediated enhancement of protein degradation.

TL;DR: There are reports showing that ID regions/domains commonly exist within proteins with modular structures such as transcription factors, and are often located in their transactivation domain, and it is important to find out their existence and functional roles in transcriptional regulations by transcription factors.

TL;DR: The internalization of human IgG in human intestine might be, at least in part, due to FcRn-mediated endocytosis, which could occur by a process other than clathrin- and caveolin-dependent mechanisms.

TL;DR: It is suggested that fatty acids are able to modulate the proliferation and differentiation of skeletal muscle and MAPKs may be involved in the modulation of theiferation and differentiation in skeletal muscle cells by fatty acids.

TL;DR: The results show that DADS analogs are effective in reducing the total lipid levels which could be correlated with a significant decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity, and their unique anti-inflammatory effect and hypolipidemic action may be beneficial in preventing the vascular complications that are induced by hyperlipidemia.

TL;DR: The present findings demonstrate alterations in nucleotide hydrolysis in platelets of STZ-induced diabetic rats and treatment with RSV was able to modulate adenine nucleotide Hydrolysis, which may be important in the control of the platelet coagulant status in diabetes.

TL;DR: The results indicated that after chronic D-Gal exposure, the spatial memory of mice was seriously impaired, whereas nonspatial cognition remained intact, and the HIP and HIP-dependent spatial cognition might be more susceptible to oxidative stress during senescence or other pathological processes.

TL;DR: The results reveal that agmatine has neuroprotective effects against TNF-alpha-induced apoptosis in retinal ganglion cells in vitro.