Hepatic vascular flow measurements by phase contrast MRI and doppler echography: A comparative and reproducibility study
Thierry Yzet,Roger Bouzerar,Jean-Dominique Allart,Fabien Demuynck,Cécile Legallais,Brice Robert,Hervé Deramond,Marc-Etienne Meyer,Olivier Balédent +8 more
TLDR
To directly compare and study the variability of parameters related to hepatic blood flow measurements using 3 T phase‐contrast magnetic resonance imaging (PC‐MRI) and Doppler ultrasound (US).Abstract:
Purpose:
To directly compare and study the variability of parameters related to hepatic blood flow measurements using 3 T phase-contrast magnetic resonance imaging (PC-MRI) and Doppler ultrasound (US).
Materials and Methods:
Nine healthy subjects were studied. Blood velocities and flow rate measurements were performed in the portal vein and the proper hepatic artery. MR studies were performed using a 3 T imager. Gradient-echo fast phase contrast sequences were used with both cardiac and respiratory gating. MR and Doppler flow parameters were extracted and compared. Two methods of calculation were used for Doppler flow rate analysis.
Results:
Compared to Doppler US, PC-MRI largely underestimated hepatic flow data with lower variability and higher reproducibility. This reproducibility was more pronounced in the portal vein than in the proper hepatic artery associated with poorer velocity correlations. Total hepatic flow values were 1239 ± 223 mL/min and 1595 ± 521 mL/min for PC-MRI and Doppler US, respectively.
Conclusion:
Free-breathing PC-MRI can provide reliable noninvasive measurement of hepatic flow parameters compared to Doppler US. The MR technique could help to improve Doppler flow calculations, thereby allowing standardization of protocols, particularly for applications in disease. J. Magn. Reson. Imaging 2010;31:579–588. © 2010 Wiley-Liss, Inc.read more
Citations
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4D flow imaging with MRI
TL;DR: The purpose of this review is to describe the methods used for 4D flow MRI acquisition, post-processing and data analysis and provide an overview of the clinical applications of 4D Flow MRI, which includes a review of applications in the heart, thoracic aorta and hepatic system.
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Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: A database for parameters required in physiologically based pharmacokinetic modelling
Khaled Abduljalil,Penny J. Furness,Trevor N. Johnson,Amin Rostami-Hodjegan,Amin Rostami-Hodjegan,Hora Soltani +5 more
TL;DR: The collected data presented in this paper provide a potentially useful singular resource for key parameters needed for PBPK modelling in pregnancy, which facilitates the risk assessment of environmental chemicals and therapeutic drug dose adjustments in the pregnant population.
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Transporter-mediated drug-drug interactions.
Fabian Müller,Martin F. Fromm +1 more
TL;DR: This article focuses on probe drugs lacking significant metabolism to highlight mechanisms of interactions of selected intestinal, hepatic and renal drug transporters and Genotype-dependent drug-drug interactions are discussed.
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Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging
Naaventhan Palaniyappan,Eleanor F. Cox,C. Bradley,Robert A H Scott,Andrew Austin,Richard O’Neill,Greg Ramjas,Simon Travis,Hilary White,Rajeev Singh,Peter Thurley,Indra Neil Guha,Susan T. Francis,Guruprasad P. Aithal +13 more
TL;DR: In this article, the authors evaluated the use of non-contrast quantitative magnetic resonance imaging (MRI) as a surrogate measure of portal pressure, and the correlation of all non-invasive parameters with HVPG was evaluated.
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Normal and altered three-dimensional portal venous hemodynamics in patients with liver cirrhosis.
Zoran Stankovic,Zoltan Csatari,Peter Deibert,Wulf Euringer,Philipp Blanke,Wolfgang Kreisel,Zahra Abdullah Zadeh,Felix Kallfass,Mathias Langer,Michael Markl +9 more
TL;DR: Flow-sensitive 4D MR imaging may constitute a promising, alternative technique to Doppler US for evaluating hemodynamics in the portal venous system of patients with liver cirrhosis and may be a means of assessing pathologic changes in flow characteristics.
References
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TL;DR: Treating ulcers with drugs strengthening mucosal defences (irrespective of which gastroprotective drug is used and regardless of H pylon) results in longer lasting healing than after treatment with gastric acid inhibitors.