Journal ArticleDOI
Hepatitis B Vaccine Administered to Chronic Carriers of Hepatitis B Surface Antigen
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TLDR
Immunization of chronic HBsAg carriers with hepatitis B vaccine, although ineffective in eliminatingHBsAg, appeared to be safe, and such safety would simplify the design of hepatitis B vaccination programs.Abstract:
We administered up to 6 monthly doses of hepatitis B vaccine to 16 chronic carriers of hepatitis B surface antigen (HBsAg) in an attempt to eliminate the antigen. The HBsAg in this vaccine differs from native antigen. No patients had elimination of HBsAg, but one of 10 no longer carried hepatitis B e antigen (HBeAg), Of 13 patients without preexisting antibody to HBsAg (anti-HBs), none acquired the antibody; two of three patients with preexisting heterotypic anti-HBs had transient, low-level increases in anti-HBs titers. Serum alanine aminotransaminase (ALT) levels fell in eight patients, remained unchanged in six, and increased transiently in two. Decreased ALT and HBeAg clearance, however, did not seem to be related to vaccination, and the transient ALT elevations appeared to represent sporadic, acute non-A, non-B hepatitis. No adverse effects other than sore arm and joint pain were seen. Immunization of chronic HBsAg carriers with hepatitis B vaccine, although ineffective in eliminating HBsAg, appeared to be safe. Such safety, if confirmed, would simplify the design of hepatitis B vaccination programs.read more
Citations
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Vaccines to prevent viral hepatitis
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TL;DR: At least five different viruses cause hepatitis in humans, and two — hepatitis A virus (HAV) and hepatitis E virus (HEV) — are nonenveloped RNA viruses that are spread predominantly by fecal–oral transmission and cause acute self-limited disease.
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Present and future therapies of hepatitis B: From discovery to cure
T. Jake Liang,Timothy M. Block,Brian J. McMahon,Marc G. Ghany,Stephan Urban,Ju-Tao Guo,Stephen Locarnini,Fabien Zoulim,Kyong-Mi Chang,Anna S. Lok +9 more
TL;DR: The current state of science in HBV therapy is reviewed and new and exciting therapeutic strategies spurred by recent scientific advances are highlighted, bringing us closer to the possibility of a functional cure of chronic HBV infection.
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Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: implications in hepatitis B vaccination programs.
TL;DR: Doubts are raised as to the reliability of anti‐HBc (Corzyme, Abbott Laboratories, North Chicago, Ill.) as a single screening test for hepatitis B infection prior to vaccination and it is suggested that subjects with isolated anti-HBc, in particular those with low anti‐ HBc titers, be included in vaccination programs.
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Guideline for infection control in hospital personnel.
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References
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Gertrude Henle,Werner Henle +1 more
TL;DR: Indirect immunofluorescence tests led to the brilliant staining of a small proportion of the cells in five different cultures derived from Burkitt's (African) lymphomas, and several observations suggest that the stainable cells might be those which are seen to harbor virus particles under the electron microscope.
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TL;DR: In this article, the efficacy of an inactivated hepatitis B vaccine in a randomized, double-blind trial in 1083 homosexual men known to be at high risk for hepatitis B virus infection was evaluated.
Journal ArticleDOI
Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers.
TL;DR: A new antigen-antibody system associated with the hepatitis B virus and immunologically distinct from the HB surface, core, and e systems is reported, and delta antibody was found in the serum of chronic HBsAg carriers, with a higher prevalence in patients with liver damage.
Journal ArticleDOI
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TL;DR: A sensitivie and simple procedure for the detection and quantitation of soluble complement (C)- fixing immune complexes in sera of patients with various disease states has been developed by utilizing C receptors on Raji cells.
Journal ArticleDOI
Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis.
TL;DR: It is suggested that many patients with chronic type B hepatitis eventually have a spontaneous remission in clinical and biochemical evidence of active disease, usually heralded or accompanied by the disappearance of HBeAg and DNA polymerase.
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