Journal ArticleDOI
Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B
Maurizia Rossana Brunetto,Manuela Giarin,Giorgio Maria Saracco,Filippo Oliveri,Pier Luigi Calvo,Gabriella Capra,A Randone,Maria Lorena Abate,Paola Manzini,M Capalbo,Piantino P,Giorgio Verme,Bonino Ferruccio +12 more
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TLDR
Precore mutant HBV can influence the response to interferon when it reaches significant serum levels (> 20% of total viremia) and chronic hepatitis B should be treated as early as possible in its natural history before precore mutant HBVs is selected as a prevalent virus.About:
This article is published in Gastroenterology.The article was published on 1993-09-01. It has received 188 citations till now. The article focuses on the topics: Hepatitis B virus & Virus.read more
Citations
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Journal ArticleDOI
Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B. Lamivudine Precore Mutant Study Group.
Nicolaos C. Tassopoulos,R Volpes,G Pastore,Jenny Heathcote,Maria Buti,Robert D. Goldin,Hawley S,Judy Barber,Condreay L,DF Gray +9 more
TL;DR: Lamivudine treatment results in a significant virological and biochemical improvement compared with placebo, induces an improvement or no change in histology in most patients, and is well tolerated.
Journal ArticleDOI
World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants
TL;DR: It is revealed that e‐CHB is more common than previously suspected and that it is present worldwide with marked variations in the prevalence of associated HBV variants across different geographical regions.
Journal ArticleDOI
HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C
TL;DR: HBV genotype B was associated with a higher rate of IFN-induced HBeAg clearance compared with genotype C, and Stratification for HBV genotypes should be considered in future clinical trials of antiviral therapy of chronic hepatitis B.
Journal ArticleDOI
Clinical relevance of hepatitis B viral mutations.
Book ChapterDOI
Naturally occurring variants of hepatitis B virus.
TL;DR: The data from extensive research on the genetic variability of HBV done during the past decade is discussed and the implications for the life cycle of the virus, immune recognition, and pathogenesis, and currently available data on the epidemiology of mutants are discussed.
References
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Journal ArticleDOI
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Robert G. Knodell,Kamal G. Ishak,William C. Black,Thomas S. Chen,Robert M. Craig,Neil Kaplowitz,T Kiernan,Jerome Wollman +7 more
TL;DR: A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis that provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions.
Journal ArticleDOI
MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION
William F. Carman,Stephanos J. Hadziyannis,Michael J. McGarvey,M. R. Jacyna,Peter Karayiannis,A Makris,Howard C. Thomas +6 more
TL;DR: To test the hypothesis that the absence of HBeAg production may be due to a change in the nucleotide sequence of the pre-core region of the genome, 18 Greek and 3 non-Greek patients positive for HB surface antigen underwent direct sequencing of HBV-DNA amplified from sera.
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Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen.
Hiroaki Okamoto,Shigeru Yotsumoto,Yoshihiro Akahane,T Yamanaka,Y Miyazaki,Yoshiki Sugai,Fumio Tsuda,Takeshi Tanaka,Yuzo Miyakawa,Makoto Mayumi +9 more
TL;DR: Results would indicate a selection of pre-C-defective mutants in persistently infected hosts, along with seroconversion to anti-HBe, by immune elimination of hepatocytes harboring nondefective HBV with the expression of HBeAg.
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Mutations in the Precore Region of Hepatitis B Virus DNA in Patients with Fulminant and Severe Hepatitis
TL;DR: The presence of a mutant viral strain is associated with and may be involved in the pathogenesis of fulminant hepatitis B and severe exacerbations of chronic hepatitis B.