Journal ArticleDOI
Herpes simplex virus proteins: DNA-binding proteins in infected cells and in the virus structure.
Reads0
Chats0
TLDR
After infection with herpes simplex virus many of the mock infected cell specific DNA binding proteins are no longer produced and this “switch off” of host cell protein synthesis is rapid.About:
This article is published in Virology.The article was published on 1975-11-01. It has received 124 citations till now. The article focuses on the topics: Single-stranded binding protein & ICP8.read more
Citations
More filters
Journal ArticleDOI
Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1.
TL;DR: The complete DNA sequence of the short unique region in the genome of herpes simplex virus type 1, strain 17, is determined, and it is deduced that several of these proteins may be membrane-associated.
Journal ArticleDOI
Herpes simplex virus DNA replication.
Paul E. Boehmer,I. R. Lehman +1 more
TL;DR: DNA replication very likely proceeds in two phases: an initial phase of theta replication, initiated at one or more of the origins, followed by a rolling-circle mode of replication, which generates concatemers that are cleaved and packaged into infectious viral particles.
Journal ArticleDOI
Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis.
TL;DR: It is proposed that the seven genes essential for plasmid replication comprise a set of genes whose products are directly involved in viral DNA synthesis.
Journal ArticleDOI
Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides.
TL;DR: A temperature-sensitive mutant produced by transfection of cells with intact DNA and a specific DNA fragment mutagenized with low levels of hydroxylamine did not make viral DNA, although temperature sensitivity of the viral DNA polymerase could not be demonstrated.
Journal ArticleDOI
A method for identifying the viral genes required for herpesvirus DNA replication
TL;DR: It is found that HSV-1 (KOS) DNA digested to completion with the restriction enzyme Xba I is as efficient as intact viral DNA in supporting the in vivo replication of cotransfected plasmids containing oriS.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.
Ian Macpherson,Michael Stoker +1 more
TL;DR: Polyoma virus induced transformation in four fibroblast clones derived from a culture of baby hamster kidney cells is found to be low, not due to these populations consisting of a mixture of genetically stable insusceptible and susceptible cells.
Journal ArticleDOI
T4 Bacteriophage Gene 32: A Structural Protein in the Replication and Recombination of DNA
Bruce Alberts,Linda Frey +1 more
TL;DR: A new type of protein essential for DNA replication and genetic recombination has been isolated from T4 bacteriophage-infected cells of E. coli and catalyses DNA denaturation and renaturation in physiological conditions in vitro.
Related Papers (5)
Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides.
Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein.
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
R W Honess,Bernard Roizman +1 more