Journal ArticleDOI
Hibernomas are characterized by rearrangements of chromosome bands 11q13-21
TLDR
Structural rearrangements of 11q13‐21 were revealed in 9 lipogenic tumors—4 hibernomas, 4 typical lipomas and I mixed myxoid and well‐differentiated liposarcoma, indicating that this segment of chromosome 11 harbors one or more genes of importance in hibernoma development.Abstract:
Cytogenetic analysis revealed structural rearrangements of 11q13-21 in 9 lipogenic tumors--4 hibernomas, 4 typical lipomas and 1 mixed myxoid and well-differentiated liposarcoma. Two hibernomas and all lipomas simultaneously showed aberrations attributable to previously recognized cytogenetic subgroups among benign adipose tissue tumors, i.e., supernumerary ring chromosomes or rearrangements of 6p, 12q13-15, or 13q. The sole anomaly in the liposarcoma was a 4-way translocation t(9;11;22;12)(q21;q13;q11;q13), an aberration that has not previously been detected in either myxoid or well-differentiated liposarcomas. Together with our 4 cases, a total of 7 cytogenetically aberrant hibernomas have been reported. Five tumors have shown rearrangements of 11q13 and 2 of 11q21, indicating that this segment of chromosome 11 harbors one or more genes of importance in hibernoma development. Rearrangements of 11q13-21 also appear to be frequent in typical lipomas; a total of 8 typical lipomas with 11q13-21 changes have been described, including those in our series. In all but 1 however, breakpoints were also found in 6p, 12q13-15, or 13q.read more
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Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Christopher D.M. Fletcher,Måns Åkerman,P. Dal Cin,I. De Wever,Nils Mandahl,Fredrik Mertens,Felix Mitelman,Juan Rosai,Anders Rydholm,R. Sciot,Giovanni Tallini,H. Van den Berghe,W.J.M. Van de Ven,R. Vanni,Helena Willén +14 more
TL;DR: It is concluded that cytogenetic abnormalities are common in lipomatous tumors, correlate reliably with morphological sub-type in many cases, and can be of diagnostic value in histologically borderline or difficult cases.
Journal ArticleDOI
The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases.
TL;DR: Hibernoma is a benign tumor found most often in adults and most commonly in the thigh, with several morphologic variants, and should not be confused with atypical lipomas or well-differentiated liposarcoma.
Journal ArticleDOI
Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group).
Juan Rosai,Måns Åkerman,P. Dal Cin,I. Dewever,Christopher D.M. Fletcher,N. Mandahl,Fredrik Mertens,Felix Mitelman,Anders Rydholm,R. Sciot,Giovanni Tallini,H. Van den Berghe,W.J.M. Van de Ven,R. Vanni,Helena Willén +14 more
TL;DR: The results support the existence of ALT as a distinct tumor subtype that is different from ordinary lipoma and from spindle or pleomorphic lipoma, albeit histogenetically closely related to them, and supports the proposed pathogenetic link between ALT and dedifferentiated liposarcoma.
Journal ArticleDOI
Loss of Retinoblastoma Protein Expression in Spindle Cell/Pleomorphic Lipomas and Cytogenetically Related Tumors: An Immunohistochemical Study With Diagnostic Implications
TL;DR: Of the soft tissue tumors associated with 13q deletions, all spindle cell lipomas, pleomorphiclipomas, and cellular angiofibromas and most mammary-type myofibroblastomas show loss of Rb expression, which reinforces the pathogenetic relationship among this group of tumors and demonstrates the potential diagnostic utility of immunohistochemistry for Rb.
Atlas of Genetics and Cytogenetics in Oncology and Haematology
TL;DR: The etiology of PNSTs is usually unknown, however, several hereditary disorders are known to predispose to benign and malignant PN STs, notably neurofibromatosis type 1 (NF1) and neurof fibrous syndrome type 2 (NF2), both of which are inherited in an autosomal dominant fashion.
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Journal ArticleDOI
Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas.
TL;DR: Based on the cytogenetic findings in all 35 lipomas, four major subgroups can be distinguished: hyperdiploid karyotypes including one or more supernumerary ring chromosomes, diploidKaryotypes with mostly balanced rearrangements involving 12q13-14, hypodiploid or diploids with other aberrations than ring chromosomes or rearrangement of 12q14, and normal karyotype groups.
Journal Article
Cytogenetic profile of 109 lipomas.
Chandrika Sreekantaiah,Stanley P.L. Leong,Constantine P. Karakousis,Daniel L. McGee,William D. Rappaport,Hugo V. Villar,David E. Neal,Susan Fleming,Albert Wankel,Peter N. Herrington,Richard H. Carmona,Avery A. Sandberg +11 more
TL;DR: Analysis of short-term cultures of lipomas revealed a correlation among karyotypic abnormalities and clinical data, such as age and sex of the patient, and tumor depth, site, and size, which may serve to identify genes involved in normal cellular growth control.
Journal ArticleDOI
Cytogenetic findings in liposarcoma correlate with histopathologic subtypes.
TL;DR: The results indicate that cytogenetic findings may provide a new criterion, not only for establishing the diagnosis of liposarcoma, but also for differentiating confusing histologic types of lipa and these lesions from other types of sarcomas.
Journal ArticleDOI
Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors
Nils Mandahl,Mattias Höglund,Fredrik Mertens,Felix Mitelman,Anders Rydholm,Helena Willén,Otte Brosjö +6 more
TL;DR: Clonal evolution occurred in 30% of the tumors and was particularly frequent in atypical lipomas, and in nine tumors classified as typical lipoma or spindle cell lipoma.
Journal Article
Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma.
TL;DR: In this paper, the authors analyzed 27 centrocytic lymphomas by Southern blot using genomic and cDNA probes flanking the first exon of PRAD1 and found that the rearrangement at both the bcl-1 and PRAD-1 locus is strongly associated with the pathogenesis of lymphoma.