Journal ArticleDOI
Higher environmental temperature-induced increase in body temperature: involvement of serotonin in GABA mediated interaction of opioidergic system.
Suchandra Ghosh,Mrinal K. Poddar +1 more
TLDR
There is an involvement of serotonergic regulation in the opioidergic-cholinergic interaction via GABA system in HET-induced increase in BT and it may be concluded that HET exposure activates the cholinergic system through the activation of opioiderGic and Serotonergic system and hence increased the BT.Abstract:
Exposure (2 h) of adult male albino rats to higher environmental temperature (HET, 40 degrees C) significantly increased body temperature (BT). Administration of (a) 5-HTP (5 mg/kg, i.p.) or morphine (1 mg/kg, i.p.) or physostigmine (0.2 mg/kg, i.p.) alone significantly increased and (b) methysergide (1 mg/kg, i.p.) or naloxone (1 mg/kg, i.p.) or atropine (5 mg/kg, i.p.) reduced the BT of both normal and HET exposed rats. Further, it was observed that morphine prevented the methysergide-induced hypothermia and 5-HTP potentiated the morphine-induced hyperthermia in both normal and HET exposed conditions. Biochemical study also indicates that serotonin metabolism was increased but GABA utilization was reduced following exposure to HET.5-HTP or bicuculline-induced hyperthermia in control and HET exposed rat was potentiated with the coadministration of bicuculline and 5-HTP. The cotreatment of bicuculline with methysergide prevented the methysergide-induced attenuation of BT of heat exposed rat, rather BT was significantly enhanced indicating that inhibition of GABA system under heat exposed condition may activate the serotonergic activity. Further (a) enhancement of (i) morphine-induced hyperthermia with physostigmine (ii) physostigmine- or morphine+physostigmine-induced increase of BT with 5-HTP and (b) reduction of (i) morphine- or morphine + 5-HTP-induced hyperthermia with atropine and (ii) atropine-induced hypothermia with 5-HTP in both normal and HET exposed conditions suggest that HET exposure activates the cholinergic system through the activation of opioidergic and serotonergic system and hence increased the BT. Thus, it may be concluded that there is an involvement of serotonergic regulation in the opioidergic-cholinergic interaction via GABA system in HET-induced increase in BT.read more
Citations
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Mood Oscillations and Coupling Between Mood and Weather in Patients with Rapid Cycling Bipolar Disorder.
TL;DR: Heterogeneity in the parameters of the differential equation model of homeostatic equilibrium as well as the coupling of mood to an inherently unpredictable process such as weather provide an alternative account for reported broadband frequency spectra of daily mood in RCBD.
Journal ArticleDOI
Sedative and hypothermic effects of γ-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: Assessment using biotelemetry
TL;DR: Biotelemetry analysis of the effects of GHB on body temperature and locomotor activity in freely moving rats and interactions between GHB and 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine (METH) and various antagonist drugs confirm a role for GABA(B) receptors in the hypothermic and sedative effects of Ghanaian drug gamma-hydroxybutyrate.
Journal ArticleDOI
Higher environmental temperature potentiates cataleptic effect of fentanyl in rats.
Sonja Vučković,Milovan D. Ivanović,Milica Prostran,Zoran Todorovic,Zorana Ristovic,Ivan V. Mićović,Dušan Beleslin +6 more
TL;DR: This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy and indicates that HET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference with behavioral thermoregulation.
Journal ArticleDOI
Modulation of delta opioid-evoked hypothermia in rats by WAY 100635 and fluoxetine
Scott M. Rawls,Alan Cowan +1 more
TL;DR: The present data reveal that 5- HT1A receptor activation mediates a significant proportion of the hypothermic response to delta opioid receptor activation and that a 5-HT uptake blockade potentiates delta receptor-induced hypothermia.
Journal ArticleDOI
Effects of GABAB-agonist on rat hypothalamic neurons: Functional antagonism with μ-receptor agonist
TL;DR: The effect on temperature sensitivity was abolished and absence of synergism in regard to firing rate decrease occurred, when baclofen and PL-017 were applied simultaneously, which are step of understanding the complicated mechanisms of action of neurotransmitters and their interactions on the level of central temperature controller.
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