How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.
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This article is published in Molecular Biology of the Cell.The article was published on 1994-03-01 and is currently open access. It has received 626 citations till now. The article focuses on the topics: Endoplasmic reticulum & STIM1.read more
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Journal ArticleDOI
Intracellular functions of N-linked glycans.
Ari Helenius,and Markus Aebi +1 more
TL;DR: The division of synthesis and processing between the ER and the Golgi complex represents an evolutionary adaptation that allows efficient exploitation of the potential of oligosaccharides.
Journal ArticleDOI
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Ari Helenius,Markus Aebi +1 more
TL;DR: From a process involved in cell wall synthesis in archaea and some bacteria, N-linked glycosylation has evolved into the most common covalent protein modification in eukaryotic cells.
Journal ArticleDOI
Setting the standards: quality control in the secretory pathway.
TL;DR: Quality control improves folding efficiency by retaining proteins in the special folding environment of the endoplasmic reticulum, and it prevents harmful effects that could be caused by the deployment of incompletely folded or assembled proteins.
Journal ArticleDOI
Protein Sorting by Transport Vesicles
TL;DR: Eukaryotic life depends on the spatial and temporal organization of cellular membrane systems and general principles that underlie a broad variety of physiological processes, including cell surface growth, the biogenesis of distinct intracellular organelles, endocytosis, and the controlled release of hormones and neurotransmitters.
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Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application
TL;DR: The structural basis for the specificity of inhibition of alkaloidal sugar mimics and their current and potential application to biomedical problems will be reviewed.
References
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Biological roles of oligosaccharides: all of the theories are correct
TL;DR: The only common features of the varied functions of oligosaccharides are that they either mediate ‘specific recognition’ events or that they provide ‘modulation’ of biological processes.
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Assembly of asparagine-linked oligosaccharides.
TL;DR: The structure of ASPARAGINE-LINKed OLIGOSACCI-IARIDES and transfer-Oligosaccharide Structural Requirements, and Sequence of Processing and Specificity of Processing Enzymes are presented.
Journal ArticleDOI
Protein folding in the cell.
TL;DR: Folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
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Synthesis and processing of asparagine-linked oligosaccharides.
S C Hubbard,R J Ivatt +1 more