Human Hippocampus Arbitrates Approach-Avoidance Conflict.
Dominik R. Bach,Dominik R. Bach,Dominik R. Bach,Marc Guitart-Masip,Marc Guitart-Masip,Pau A. Packard,Júlia Miró,Mercè Falip,Lluís Fuentemilla,Raymond J. Dolan,Raymond J. Dolan +10 more
TLDR
The data provide the first human assay for approach-avoidance conflict akin to that of animal anxiety models and furnish a framework for addressing the neuronal underpinnings of human anxiety disorders, where the data indicate a major role for the hippocampus.About:
This article is published in Current Biology.The article was published on 2014-03-03 and is currently open access. It has received 142 citations till now.read more
Citations
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The role of the hippocampus in approach-avoidance conflict decision-making: Evidence from rodent and human studies.
Rutsuko Ito,Andy C. H. Lee +1 more
TL;DR: There is substantial, converging cross-species evidence to support the idea that the hippocampus, in particular the ventral (in rodents)/anterior (in humans) portion, contributes to approach-avoidance conflict decision making and it is suggested that the seemingly disparate functions of the HPC need not be mutually exclusive.
Journal ArticleDOI
Foraging for foundations in decision neuroscience: insights from ethology
TL;DR: It is argued that more should be done to combine the approaches taken in neuroscience with those taken in ethology and behavioural ecology to study decision-making, and illustrated how this has been achieved in the context of studies on foraging.
Journal ArticleDOI
Comparing and Contrasting the Cognitive Effects of Hippocampal and Ventromedial Prefrontal Cortex Damage: A Review of Human Lesion Studies
TL;DR: This work directly compared the cognitive changes in humans with either bilateral hippocampal or bilateral vmPFC damage and proposed a hierarchical network model wherevmPFC initiates mental imagery including hippocampal scene construction.
Journal ArticleDOI
Reconciling the different faces of hippocampal theta: the role of theta oscillations in cognitive, emotional and innate behaviors
Tatiana Korotkova,Tatiana Korotkova,Alexey Ponomarenko,Caitlin K. Monaghan,Steven L. Poulter,Francesca Cacucci,Thomas J. Wills,Michael E. Hasselmo,Colin Lever +8 more
TL;DR: A complex interplay of neuronal circuits and synchronization features enables an adaptive regulation of multiple behaviors by theta-rhythmic signaling in cognitive functions, including spatial coding and memory, exploratory locomotion and anxiety-related behaviors.
Journal ArticleDOI
An elevated plus-maze in mixed reality for studying human anxiety-related behavior.
Sarah V. Biedermann,Daniel G. Biedermann,Frederike Wenzlaff,Tim Kurjak,Sawis Nouri,Matthias K. Auer,Matthias K. Auer,Klaus Wiedemann,Peer Briken,Jan Haaker,Tina B. Lonsdorf,Johannes Fuss +11 more
TL;DR: These findings demonstrate cross-species validity of open arm avoidance as a translational measure of anxiety and introduce the first ecologically valid assay to track actual human approach-avoidance behavior under laboratory conditions.
References
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Theory of Games and Economic Behavior
TL;DR: Theory of games and economic behavior as mentioned in this paper is the classic work upon which modern-day game theory is based, and it has been widely used to analyze a host of real-world phenomena from arms races to optimal policy choices of presidential candidates, from vaccination policy to major league baseball salary negotiations.
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Emotion Circuits in the Brain
TL;DR: The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area, and much of the progress has come from studies of fear, and especially fear conditioning as mentioned in this paper.
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A fast diffeomorphic image registration algorithm
TL;DR: DARTEL has been applied to intersubject registration of 471 whole brain images, and the resulting deformations were evaluated in terms of how well they encode the shape information necessary to separate male and female subjects and to predict the ages of the subjects.
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Theory of Games and Economic Behavior
TL;DR: In this article, the authors show that the maximization of individual wealth is not an ordinary problem in variational calculus, because the individual does not control, and may even be ignorant of, some of the variables.
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The ‘Trier Social Stress Test’ – A Tool for Investigating Psychobiological Stress Responses in a Laboratory Setting
TL;DR: The results suggest that gender, genetics and nicotine consumption can influence the individual's stress responsiveness to psychological stress while personality traits showed no correlation with cortisol responses to TSST stimulation.