Journal ArticleDOI
Human IgG subclasses in health and disease. (A review). Part I.
Farouk Shakib,D.R. Stanworth +1 more
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This article is published in La Ricerca in Clinica E in Laboratorio.The article was published on 1980-07-01. It has received 133 citations till now.read more
Citations
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Evaluation of Monoclonal-antibodies Having Specificity for Human-igg Sub-classes - Results of An Iuis Who Collaborative Study
Royston Jefferis,Charles B. Reimer,F. Skvaril,G. G. de Lange,D.M. Goodall,T.L. Bentley,Donald J. Phillips,A. Vlug,S. Harada,J. Radl,E. Claassen,J.A. Boersma,J. Coolen +12 more
TL;DR: IgG1 and IgG2 were the least immunogenic of the sub-class proteins and there is evidence that epitope display is influenced by the physical and chemical procedures used to immobilize or fix antigen - a common requirement in the assay systems studied.
Journal ArticleDOI
Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome
Motohisa Yamamoto,S. Harada,Mikiko Ohara,Chisako Suzuki,Yasuyoshi Naishiro,Hiroyuki Yamamoto,Hiroki Takahashi,Kohzoh Imai +7 more
TL;DR: Mikulicz's disease is suggested to be an IgG4-related systemic disease and Histopathologically, only MD was associated with prominent infiltration of IgG 4-positive plasmacytes into lachrymal and salivary glands.
Journal ArticleDOI
Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon
TL;DR: A significantly higher median proportion of IgG1 immunocytes was found in ulcerative colitis than in Crohn's colitis, and this disparity might reflect dissimilar mucosal exposure to mitogenetic or antigenic stimuli or genetically determined immunoregulatory differences in the two categories of patients.
Journal ArticleDOI
Human Immunoglobulin G and Immunoglobulin G Subclasses: Biochemical, Genetic, and Clinical Aspects
Christine Papadea,Irene J. Check +1 more
TL;DR: IgG isotype selectivity has been recognized in autoimmune diseases and in response to carbohydrate and protein antigens derived from pathogenic microorganisms and common allergens.
Journal ArticleDOI
Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity.
TL;DR: It is found that Fc-galactosylation enhances the efficacy of CD20-targeting complement-fixing antibodies for C1q binding and complement-mediated tumor cell lysis, indicating that F c galactose can be harnessed to enhance the complement-activating properties of IgG1 and IgG3 antibodies.
References
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Journal ArticleDOI
Biologic and clinical significance of cryoglobulins. A report of 86 cases.
TL;DR: In this series, immunoproliferative and autoimmune disorders were the most frequent diseases associated with cryoglobulinemia and no treatment was definitively effective in patients with chronic symptoms such as vascular purpura.
Journal ArticleDOI
Immunoelectrophoretic method for the analysis of mixtures of antigenic substances
Pierre Grabar,Curtis A. Williams +1 more
TL;DR: In this paper, an electrophorese du produit a etudier dans un gel de gelose a 1.5-2% dans a tampon veronal de λ 2 = 0.05 and aved une chute de potentiel de 3-4 V/cm dans le gel.
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Serum levels of immune globulins in health and disease: a survey
E R Stiehm,H H Fudenberg +1 more
TL;DR: There was significant elevation of levels of γG-, γA-, and total γ-globulins, and diminution of that ofγM in the serum of mongols over 10 years of age, and the diminutions may be implicated in the poor response of m Mongols to immunizing antigens and the increased susceptibility of such patients to infections.
Journal ArticleDOI
Metabolic properties of IgG subclasses in man
TL;DR: Metabolic properties of the four subclasses of human IgG were investigated by performing 47 turnover studies in individuals with normal IgG serum concentrations, as well as in patients with an increased level of one of the subclasses, showing that an elevated serum concentration of any IgG subclass was associated with shortened biologic half-life and increased fractional catabolic rate of all subclasses.