Hydrogenosome, a Cytoplasmic Organelle of the Anaerobic Flagellate Tritrichomonas foetus, and Its Role in Pyruvate Metabolism
Donald G. Lindmark,Miklós Müller +1 more
TLDR
Homogenates of Tritrichomonas foetus have pyruvate synthase and hydrogenase, but lack pyruVate-formate lyase and formate dehydrogenase, and these activities are in a subcellular particle identified previously as the site of malate and α-glycerophosphate dehydrogensases.About:
This article is published in Journal of Biological Chemistry.The article was published on 1973-11-25 and is currently open access. It has received 403 citations till now. The article focuses on the topics: Pyruvate synthase & Pyruvate dehydrogenase complex.read more
Citations
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Energy conservation in chemotrophic anaerobic bacteria.
TL;DR: This article corrects the article on p. 100 in vol.
Journal ArticleDOI
On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells
TL;DR: The universal ancestor the authors infer was not a free-living cell, but rather was confined to the naturally chemiosmotic, FeS compartments within which the synthesis of its constituents occurred, leading to the emergence of prokaryotic lineages from inorganic confines.
Journal ArticleDOI
Clinical and Microbiological Aspects of Trichomonas vaginalis
TL;DR: These studies have illustrated that the pathogenesis of T. vaginalis is indeed very complex and involves adhesion, hemolysis, and soluble factors such as cysteine proteinases and cell-detaching factor, and certain stress responses enable the organism to survive in its changing environment.
Journal ArticleDOI
Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
Miklós Müller,Marek Mentel,Jaap J. van Hellemond,Katrin Henze,Christian Woehle,Sven B. Gould,Re-Young Yu,Mark van der Giezen,Aloysius G.M. Tielens,William Martin +9 more
TL;DR: The gene distribution across lineages reflects the presence of anaerobic energy metabolism in the eukaryote common ancestor and differential loss during the specialization of some lineages to oxic niches, just as oxphos capabilities have been differentially lost in specialization to anoxic niches and the parasitic life-style.
Book ChapterDOI
The endosymbiont hypothesis revisited.
TL;DR: This chapter highlights endosymbiont hypothesis, which states that all contemporary genomes ultimately derive from a single genome—the genome of a single, presumably cellular, entity which was the ancestor of all surviving forms of live.
References
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Journal ArticleDOI
Evolutionary and systematic relationships in the flagellate order Trichomonadida Kirby.
TL;DR: Two new species, one of Monocercomonas and another of Tritrichomonas are named and diagnosed and the paper includes a key to all the families and subfamilies of the order and to the genera of Mono-monadidae and Trichomonadidae.
Journal ArticleDOI
Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme.
Kosaku Uyeda,Jesse C. Rabinowitz +1 more
TL;DR: Pyruvate-ferredoxin oxidoreductase has been purified to 90% homogeneity from Clostridium acidi-urici and the three enzymic activities determined are not dependent on the addition of thiamine pyrophosphate when tested with the purified enzyme, but they are dependent onThe addition of the cofactor when an aged crude preparation is used.
Journal ArticleDOI
Biochemical cytology of trichomonad flagellates. I. Subcellular localization of hydrolases, dehydrogenases, and catalase in Tritrichomonas foetus.
TL;DR: To determine the localization of several enzymes in Tritrichomonas foetus, the axenic KV-1 strain was grown in Diamond's medium with bovine serum, homogenized in 0.25 M sucrose, and subjected to analytical differential and isopycnic centrifugation.
Journal ArticleDOI
Properties and function of the pyruvate-formate-lyase reaction in clostridiae
TL;DR: The pattern of enzymes related to the synthesis of C1 units by several clostridia demonstrates that either a pyruvate-formate-lyase or a CO2-reductase reaction leads to the formation of formate, which is required for the synthesis in these bacteria.
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