Journal ArticleDOI
Immune responses in mice to tumour challenge after immunization with newcastle disease virus‐infected or X‐irradiated tumour cells or cell fractions
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TLDR
Preimmunization with homologous virus (NDV) prior to inoculation with a virus‐containing tumour cell fraction did not in this system enhance the immune response against tumour challenge.Abstract:
Cells of the transplantable ascites tumour sarcoma 37 (S37) have been infected in vitro with Newcastle disease virus (NDV). Infected cells, a virus-containing fraction of such cells, and X-irradiated S37 cells have been found to immunize mice against subsequent tumour challenge. Anti-lymphocyte serum and anti-theta serum interfered with this immune response. The level of humoral anti-tumour antibody did not correlate with immunity. Preimmunization with homologous virus (NDV) prior to inoculation with a virus-containing tumour cell fraction did not in this system enhance the immune response against tumour challenge. The implications of these findings are discussed. Caution is advocated in applying the results of experiments with such animal tumour virus models to the human clinical situation.read more
Citations
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Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Patent
Treatment of neoplasms with viruses
TL;DR: In this article, the authors proposed a method for the selection, design, purification and use of such viruses for cancer therapy, and used them in treating neoplastic disease including cancer and large tumors.
Journal ArticleDOI
Prevention of metastatic spread by postoperative immunotherapy with virally modified autologous tumor cells. I. Parameters for optimal therapeutic effects.
TL;DR: Effective anti‐metastatic therapy was achieved in a mouse tumor model by combining surgery with postoperative immunotherapy using virus‐modified autologous tumor cells using Newcastle disease virus, which led to expression of viral antigens and to an increase in the tumor cells' immunogenicity.
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Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice.
A H Greenberg,J H Playfair +1 more
Book ChapterDOI
Virus Augmentation of The Antigenicity of Tumor Cell
Faye C. Austin,Charles W. Boone +1 more
TL;DR: The augmented immunogenicity of virus-infected tumor cell extracts is evaluated by animal model studies, immunotherapy of human cancer, and immunodiagnosis ofhuman cancer with virus-augmented skin test antigens.
References
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Journal ArticleDOI
Theta isoantigen as a marker of thymus-derived lymphocytes in mice.
TL;DR: In this paper, the theta (θ) isoantigen is determined by a single locus with two alleles: θAKR and RF mice and θC3H present in most other inbred strains of mice tested, which is found chiefly in thymus lymphocytes and brain, and to a lesser extent in peripheral lymphocytes in mice.
Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Journal ArticleDOI
The requirement of more than one antigenic determinant for immunogenicity
TL;DR: The immune stimulus leading to antibody formation requires the interaction of two antigen-bridged cells and it is suggested that the receptors for recognition of unrelated determinants are probably situated on different cells.
Journal ArticleDOI
Cooperation of Immune Lymphoid Cells with Macrophages in Tumour Immunity
R Evans,P Alexander +1 more
TL;DR: An immunologically specific cellular cooperation may resolve the paradox that immune spleen cells injected into normal mice prevent the growth of lymphoma cells in vivo but fail to do so in vitro.
Journal ArticleDOI
Some experiments on the action of antilymphoid antisera
R. H. Levey,P. B. Medawar +1 more
TL;DR: Although there seems little doubt that the life of homografts could be prolonged indefinitely by the judicious use of antisera, this work has devoted no attention to achieving longevity for its own sake; nor has it made use of thymectomy or thoracic duct drainage as auxiliary methods of immunosuppression.
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