Journal ArticleDOI
In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients†
Brian J. F. Wong,Ryan P. Jackson,Shuguang Guo,James M. Ridgway,Usama Mahmood,Jianping Su,Terry Y. Shibuya,Roger L. Crumley,Mai Gu,William B. Armstrong,Zhongping Chen +10 more
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TLDR
Patients undergoing surgical head and neck endoscopy were examined using a fiberoptic OCT imaging probe to study and characterize microstructural anatomy and features of the larynx and benign laryngeal pathology in vivo.Abstract:
Objectives: Optical coherence tomography (OCT) is an emerging imaging modality that combines lowcoherence light with interferometry to produce crosssectional images of tissue with resolution about 10 m. Patients undergoing surgical head and neck endoscopy were examined using a fiberoptic OCT imaging probe to study and characterize microstructural anatomy and features of the larynx and benign laryngeal pathology in vivo. Study Design: Prospective clinical trial. Materials and Methods: OCT imaging of the larynx was performed in 82 of 115 patients who underwent surgical endoscopy for various head and neck pathologies. The OCT device employs a 1.3 m broadband light source (FWHM, 80 nm). The frame rate is 1 Hz. Imaging was performed using a handheld probe placed in near contact with the target site. The maximum axial and lateral dimensions for the region of interest imaged were 2.5 mm 6 mm, with resolutions of 10 m. Simultaneously, conventional endoscopic images were obtained to provide anatomic correlation with OCT images and histology. Optical micrometry was performed to measure the epithelium thickness. Results: Systematic OCT imaging of laryngeal structures and subsites provided information on the thickness of the epithelium, integrity of the basement membrane, and structure of the lamina propria. Microstructural features identified included glands, ducts, blood vessels, fluid collection/edema, and the transitions between pseudostratified columnar and stratified squamous epithelium. The mean epithelial thickness of laryngeal subsites was calculated: true vocal cord (129 m), false vocal cords (124 m), aryepiglottic fold (177 m), subglottis (98 m), and epiglottis (185 m). True vocal cord pathology imaged included Reinke’s edema, papillomatosis, polyps, mucous cysts, and granulation tissue. Subglottic imaging identified boundaries between epithelium, lamina propria, and cartilage. The OCT images compared favorably with conventional histopathology. Conclusion: OCT has the unique ability to image laryngeal tissue microstructure and can detail microanatomic changes in benign, premalignant, and malignant laryngeal pathologies. OCT holds the potential to guide surgical biopsies, direct therapy, and monitor disease, particularly when office-based systems are developed. This is a promising imaging modality to study the larynx. Key Words: Optical coherence tomography, larynx, vocal cord, vocal cord polyps, laryngeal cancer, Reinke’s edema, endoscopy, optical biopsy, respiratory papillomas, hyperkeratosis, laryngology. Laryngoscope, 115:1904–1911, 2005read more
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Journal ArticleDOI
Optical coherence tomography: a review of clinical development from bench to bedside
TL;DR: A brief history of OCT development is presented, current clinical applications are reviewed, some clinical translation challenges are discussed, and laboratory developments poised for future clinical application are reviewed.
Journal ArticleDOI
Endoscopic optical coherence tomography: Technologies and clinical applications [invited]
TL;DR: The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions, and key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-Viewing probes, along with different scanning mechanisms.
Journal ArticleDOI
Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography
Ki Hean Kim,B. Hyle Park,Gopi N. Maguluri,Tommy W. Lee,Fran J. Rogomentich,Mirela G. Bancu,Brett E. Bouma,Johannes F. de Boer,Jonathan J. Bernstein +8 more
TL;DR: A two-axis scanning catheter was developed for 3D endoscopic imaging with spectral domain optical coherence tomography (SD-OCT) with microelectromechanical systems (MEMS) technology and both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s.
Journal ArticleDOI
Effective indicators for diagnosis of oral cancer using optical coherence tomography
Meng-Tsan Tsai,Hsiang-Chieh Lee,Cheng-Kuang Lee,Chuan-Hang Yu,Hsin-Ming Chen,Chun-Pin Chiang,Cheng-Chang Chang,Yih-Ming Wang,Chih-Chung Yang +8 more
TL;DR: A swept-source optical coherence tomography system is used to clinically scan oral precancer and cancer patients for statistically analyzing the effective indicators of diagnosis and it is found that SD and alpha are good diagnosis indicators for moderate dysplasia and squamous cell carcinoma.
Journal ArticleDOI
Optical Coherence Tomography of Laryngeal Cancer
William B. Armstrong,James M. Ridgway,David E. Vokes,Shuguang Guo,Jorge Perez,Ryan P. Jackson,Mai Gu,Jianping Su,Roger L. Crumley,Terry Y. Shibuya,Usama Mahmood,Zhongping Chen,Brian J. F. Wong +12 more
TL;DR: The ability of OCT to identify the characteristics of laryngeal cancer and measure changes in the basement membrane, tissue microstructure, and the transition zone at the edge of tumors is evaluated.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Journal ArticleDOI
Optical Coherence Tomography
TL;DR: Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
PatentDOI
Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
TL;DR: Using the phase change between sequential scans to construct flow-velocity imaging, this technique decouples spatial resolution and velocity sensitivity in flow images and increases imaging speed by more than 2 orders of magnitude without compromising spatial resolution or velocity sensitivity.
Journal ArticleDOI
In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa.
Alexander M. Sergeev,Valentin M. Gelikonov,Grigory V. Gelikonov,Felix I. Feldchtein,Roman V. Kuranov,Natalia D. Gladkova,Natalia M. Shakhova,Ludmila B. Snopova,A. V. Shakhov,I. A. Kuznetzova,A. N. Denisenko,V. V. Pochinko,Yu. P. Chumakov,Olga Streltzova +13 more
TL;DR: Violations of well-defined stratified healthy mucosa structure in cancered tissue are distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.
Journal ArticleDOI
Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber
TL;DR: An ultrahigh-resolution optical coherence tomographic system in which broadband continuum generation from a photonic crystal fiber is used to produce high longitudinal resolution is developed and subcellular imaging is demonstrated.