Journal ArticleDOI
Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited.
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In this paper, the binding of carboplatin to calf thymus DNA in the presence of thiourea, glutathione, and human breast cancer MCF-7 cell cytoplasmic extracts by measurement of DNA-dependent ethidium bromide fluorescence and atomic absorption spectroscopy was studied.About:
This article is published in Biochemical Pharmacology.The article was published on 1999-11-15. It has received 37 citations till now. The article focuses on the topics: Carboplatin & Cisplatin.read more
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Journal ArticleDOI
Cisplatin in cancer therapy: molecular mechanisms of action
Shaloam Dasari,Paul B. Tchounwou +1 more
TL;DR: This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the treatment of various human cancers.
Book ChapterDOI
DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair.
TL;DR: The present article demonstrates that there is strong support for the view that either platinum or ruthenium drugs, which bind to DNA in a fundamentally different manner from that of 'classical' cisplatin, have altered pharmacological properties.
Journal ArticleDOI
Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action.
TL;DR: The presented results indicate that cobalt-alkyne complexes of the Co-ASS type, represent a new class of organometallic cytostatics with a mode of drug action in which COX inhibition probably plays a major role.
Journal ArticleDOI
Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates.
Anna Notaro,Gilles Gasser +1 more
TL;DR: A complete overview of a specific class of antiproliferative ruthenium complexes, namely coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes is given, which implies that the cytotoxicity observed comes from the entire complex and not from ligand-exchange.
Journal ArticleDOI
Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules
Luciano Oehninger,Maria Stefanopoulou,Hamed Alborzinia,Julia Schur,Stephanie Ludewig,Kazuhiko Namikawa,Alvaro Muñoz-Castro,Reinhard W. Köster,Knut Baumann,Stefan Wölfl,William S. Sheldrick,Ingo Ott +11 more
TL;DR: Ruthenium complexes of the type (p-cymene)(NHC)RuCl(2) interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B andounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved.
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Journal ArticleDOI
Structural aspects of platinum anticancer drug interactions with DNA
Journal Article
Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA.
TL;DR: It was concluded that the CBDCA ligand becomes a more labile leaving group once carboplatin has been monoaquated, and both chloro-ligands of cisplatin were shown to leave at similar rates, while certain cell lines were showed to be much more sensitive to DNA bound platinum.
Journal ArticleDOI
Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin.
Pieter M. Pil,Stephen J. Lippard +1 more
TL;DR: Recombinant rat HMG1 binds specifically to DNA containing cisplatin d(GpG) or d(ApG) intrastrand cross-links, but not to DNA modified by therapeutically inactive platinum analogs.
Journal ArticleDOI
Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II
Calvert Ah,Harland Sj,D. R. Newell,Z. H. Siddik,A. C. Jones,T. J. McElwain,S. Raju,Eve Wiltshaw,I.E. Smith,J. M. Baker,M. J. Peckham,Kenneth R. Harrap +11 more
TL;DR: JM8 is not significantly nephrotoxic and is less emetic than cisplatin, but has antitumour activity in man and deserves wider evaluation, along with the other analogues under study in various centres, as an alternative to cis Platin.
Journal ArticleDOI
Binding of platinum and palladium metallointercalation reagents and antitumor drugs to closed and open DNAs.
TL;DR: Long-term interactions of metal complexes with PM-2 DNAs I, I0, and II, corresponding tosuperhelical, closed relaxed, and nicked circles, showed that covalent binding occurs the most readily to DNA I, possibly because of the presence of underwound duplex regions in this tightly wound superhelical DNA.