Journal ArticleDOI
Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis
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TLDR
In this paper, the levels of interleukin-2, interlet-4, interleuxin-5 and interletin-10 were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometrial cancer.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1996-05-01. It has received 143 citations till now. The article focuses on the topics: Peritoneal fluid & Endometriosis.read more
Citations
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Journal ArticleDOI
Role of cytokines in endometriosis.
TL;DR: Cytokines, which are produced by many cell types including endometriotic tissues, play diverse roles in the pathogenesis ofendometriosis and endometRIosis-associated infertility and more studies about the specific role of these cells and soluble factors are needed to improve understanding of endometiosis and to develop novel therapies.
Journal ArticleDOI
Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial
Mohamed A. Bedaiwy,Tommaso Falcone,Rakesh Sharma,J.M. Goldberg,Marjan Attaran,David R. Nelson,Ashok Agarwal +6 more
TL;DR: By measuring serum IL-6 and PF TNF-alpha, it was possible to discriminate between patients with endometriosis and those without, and before these markers can be used as a non-surgical diagnostic tool, these data should be verified in a larger study.
Journal ArticleDOI
The Role of Cytokines in Endometriosis
Ming Yih Wu,Hong Nerng Ho +1 more
TL;DR: The aim is to review the literature on the role of peritoneal cytokines in the pathogenesis and endometriosis‐related infertility and to establish a baseline for this review.
Journal ArticleDOI
Pathogenic mechanisms in endometriosis-associated infertility.
TL;DR: The mechanisms of infertility associated with endometriosis remain controversial and include abnormal folliculogenesis, elevated oxidative stress, altered immune function, and hormonal milieu in the follicular and peritoneal environments, and reduced endometrial receptivity.
Journal ArticleDOI
Theories of endometriosis
TL;DR: The failure to clear the peritoneal cavity of fragments of endometrium could cause a state of local inflammation with hyperactivation of macrophages secreting a variety of different compounds.
References
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Journal ArticleDOI
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.
Journal Article
Revised American Fertility Society classification of endometriosis: 1985
W. C. Andrews,V. C. Buttram,S. J. Behrman,E. Carmichael,M. R. Cohen,P. Dmowski,R. D. Eward,David S. Guzick,H. W. Jones,R. W. Kistner,J. C. Weed,Charles B. Hammond,H. H. Thomas +12 more
Book ChapterDOI
Interleukin-6 in biology and medicine
TL;DR: Application of IL-6 is promising in cancer treatment as well as in treatment of radiation- or chemotherapy-induced myelosuppression and the cell biology of the intracellular events that link transduction to gene regulation is an important area, and work on these topics helps to understand such phenomena as multifunction of IL -6 and bidirectional effects of cell growth depending on the cell type.
Book ChapterDOI
Heterogeneity of cytokine secretion patterns and functions of helper T cells.
Tim R. Mosmann,Robert L. Coffman +1 more
TL;DR: Because cytokine functions are complex and overlapping, the development of precise, monospecific bioassays, and enzyme-linked immunosorbent assays (ELISAs) was essential, before a clear picture of T cell cytokine synthesis could be obtained.
Book ChapterDOI
Properties and functions of interleukin-10.
TL;DR: The early results regarding IL10 production and IL10 interventions in vivo suggest that IL10 can be deleterious to situations in which a delayed type hypersensitivity response is required, for example many intracellular pathogen infections.