Journal ArticleDOI
Increasing health burden of human babesiosis in endemic sites.
Peter J. Krause,Kathleen McKay,Joseph Gadbaw,Diane Christianson,Linda Closter,Timothy J. Lepore,Sam R. Telford,Vijay K. Sikand,Raymond W. Ryan,David H. Persing,Justin D. Radolf,Andrew Spielman +11 more
TLDR
Babiesial incidence at endemic sites in southern New England appears to have risen during the 1990s to a level approaching that due to borreliosis, and more older adults were admitted to hospital than younger adults.Abstract:
Human infection due to Babesia microti has been regarded as infrequent and a condition primarily affecting the elderly or immunocompromised. To determine whether risk in endemic sites may be increasing relative to that of Borrelia burgdorferi and to define its age-related clinical spectrum, we carried out a 10-year community-based serosurvey and case finding study on Block Island, Rhode Island. Less intensive observations were conducted in nearby sites. Incidence of babesial infection on Block Island increased during the early 1990s, reaching a level about three-fourths that of borrelial infection. The sera of approximately one-tenth of Block Island residents reacted against babesial antigen, a seroprevalence similar to those on Prudence Island and in southeastern Connecticut. Although the number and duration of babesial symptoms in people older than 50 years of age approximated those in people 20 to 49 years of age, more older adults were admitted to hospital than younger adults. Few Babesia-infected children were hospitalized. Babesial incidence at endemic sites in southern New England appears to have risen during the 1990s to a level approaching that due to borreliosis.read more
Citations
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Journal ArticleDOI
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Gary P. Wormser,Raymond J. Dattwyler,Eugene D. Shapiro,John J. Halperin,Allen C. Steere,Mark S. Klempner,Peter J. Krause,Johan S. Bakken,Franc Strle,Gerold Stanek,Linda K. Bockenstedt,Durland Fish,J. Stephen Dumler,Robert B. Nadelman +13 more
TL;DR: These updated guidelines replace the previous treatment guidelines published in 2000 and list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided.
Journal ArticleDOI
Babesiosis: recent insights into an ancient disease.
TL;DR: Recent insights into human babesiosis with regard to phylogeny, diagnostics and treatment are covered in order to provide new information on well known as well as recently discovered parasites with zoonotic potential.
Journal ArticleDOI
Persistent and relapsing babesiosis in immunocompromised patients.
Peter J. Krause,Benjamin E. Gewurz,Benjamin E. Gewurz,David R. Hill,Francisco M. Marty,Edouard Vannier,Ivo M. Foppa,Richard R. Furman,Ellen Neuhaus,Gail Skowron,Shaili Gupta,Carlo McCalla,Edward L. Pesanti,Mary Young,Donald Heiman,Gunther Hsue,Jeffrey A. Gelfand,Gary P. Wormser,John Dickason,Frank J. Bia,Barry J. Hartman,Sam R. Telford,Diane Christianson,Kenneth R. Dardick,Morton Coleman,Jennifer E Girotto,Andrew Spielman +26 more
TL;DR: This retrospective case-control study compared the immunologic status, clinical course, and treatment of 14 case patients who experienced morbidity or death after persistence of Babesia microti infection, despite repeated courses of antibabesial treatment with those of 46 control subjects whose infection resolved after a single course of standard therapy.
Journal ArticleDOI
Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences.
TL;DR: Interdisciplinary studies in ticks, reservoir hosts, and humans indicate that coinfection with B. burgdorferi and B. microti is common, promotes transmission and emergence of B.microti in the enzootic cycle, and causes greater disease severity and duration in humans.
Journal ArticleDOI
Natural history of Zoonotic Babesia: Role of wildlife reservoirs.
TL;DR: Graphical abstract Highlights ► All zoonotic Babesia utilize mammals, primarily wildlife, as reservoirs, and Reservoirs and/or ticks are unknown for many zoonosis species.
References
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Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Western Blotting in the Serodiagnosis of Lyme Disease
TL;DR: Western blotting can be used to increase the specificity of serologic testing in Lyme disease.
Journal ArticleDOI
Ecology of Ixodes dammini-borne human babesiosis and Lyme disease
TL;DR: The number of diseases transmitted by Ixodes ticks is remarkable; European I. ricinus and Siberian I. persulcatus each have been incriminated as vectors of ten or more infections, and North American I. dammini serves as vector for at least two as discussed by the authors.
Journal ArticleDOI
Human babesiosis : an emerging tick-borne disease
TL;DR: Identification of human infection with Babesia spp.
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Persistent and relapsing babesiosis in immunocompromised patients.
Peter J. Krause,Benjamin E. Gewurz,Benjamin E. Gewurz,David R. Hill,Francisco M. Marty,Edouard Vannier,Ivo M. Foppa,Richard R. Furman,Ellen Neuhaus,Gail Skowron,Shaili Gupta,Carlo McCalla,Edward L. Pesanti,Mary Young,Donald Heiman,Gunther Hsue,Jeffrey A. Gelfand,Gary P. Wormser,John Dickason,Frank J. Bia,Barry J. Hartman,Sam R. Telford,Diane Christianson,Kenneth R. Dardick,Morton Coleman,Jennifer E Girotto,Andrew Spielman +26 more