Journal ArticleDOI
Induction of Unscheduled DNA Synthesis in Gastric Mucosa Treated in vivo with Betel Ingredients
Soumitra Sen,Geeta Talukder,Archana Sharma +2 more
- Vol. 27, Iss: 2, pp 74-80
TLDR
Induction of unscheduled DNA synthesis in the stomach pyloric mucosa of inbred Swiss albino mice and C3H mice was examined in vitro following administration of various combinations of betel quid ingredients to assess cytotoxicity.Abstract:
Induction of unscheduled DNA synthesis (UDS) in the stomach pyloric mucosa of inbred Swiss albino mice and C3H mice was examined in vitro following administration of various combinations of betel quid ingredients in vivo Effect of the quid ingredients on replicative DNA synthesis was studied to assess cytotoxicity Betel leaf, areca nut, lime, tobacco and two popular brands of Indian chewing mixtures induced UDS to a very significant extent While addition of betel leaf reduces the UDS, tobacco significantly increases it Study of replicative DNA synthesis revealed that extracts of areca nut, nut with lime and both the brands of commercial chewing mixtures tested induced replicative DNA synthesis The genotoxic and cytotoxic potential of the test compounds provide quantitative risk factors, especially in the light of their growing use in Asian countriesread more
Citations
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Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo
TL;DR: The use of green plant parts in modifying the genotoxicity of different agents may be related to the protective action of chlorophyllin, which was tested in vivo on mice bone marrow cells.
Journal ArticleDOI
Effect of 'Pan Masala' on the germ cells of male mice.
TL;DR: Pan Masala is a potent clastogen, reaches the testes and affects the germinal cells, and indicates that sperm head abnormalities were significantly high for all the doses tested.
Journal ArticleDOI
Betel Cytotoxicity: Further Evidence from Mouse Bone Marrow Cells
TL;DR: Tobacco, in any combination of chewing mixture, induced time-dependent clastogenicity and direct damage to chromosomes was observed in the early stage, and lethal effects were observed inThe latter stages of the study.
Journal ArticleDOI
Sequential Histologic Alterations of Mouse Gastric Mucosa Following Long-Term Simulation of Betel Addiction
TL;DR: The Histopathological Effect Of Chewing Of Betel Quid Without Tobacco Was Studied By Simulating 14 Different Chewing Habits Using The Mouse Glandular Stomach Mucosa As A Model Mammalian System to Find Out Whether These Changes Were Erosions and Regenerative Hyperplasia Of The Pyloric Glands.
References
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Journal ArticleDOI
Estimates of the worldwide frequency of sixteen major cancers in 1980.
TL;DR: The numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated and it is suggested that, with declining incidence rates for stomach cancer and the continuing rise for lung cancer, the latter would become the most common cancer in the world by the end of 1981.
Journal Article
Two Forms of Repair in the DNA of Human Cells Damaged by Chemical Carcinogens and Mutagens
James D. Regan,R. B. Setlow +1 more
TL;DR: DNA repair in human cells, as assayed by the photolysis of 5-bromodeoxyuridine incorporated during repair, takes one of two limiting forms, depending on the nature of the original insult to the DNA.
Journal ArticleDOI
Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment
D. J. Jussawalla,V. A. Deshpande +1 more
TL;DR: It is revealing to find that the high risk sites involved in tobacco chewers appear to be the least affected in smokers, and vice versa.
Journal ArticleDOI
Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients.
TL;DR: The data suggest a possible role of reactive oxygen species in the etiology of oral cancer in betel quid chewers.
Journal ArticleDOI
Hydroxychavicol: a new phenolic antimutagen from betel leaf
TL;DR: Neither eugenol nor hydroxychavicol was mutagenic when tested in various strains of Salmonella typhimurium with or without metabolic activation, but both compounds exhibited dose-dependent suppression of dimethylbenzanthracene-induced mutagenesis in S. typhimuratium strain TA98.