Journal ArticleDOI
Betel Cytotoxicity: Further Evidence from Mouse Bone Marrow Cells
Soumitra Sen,Geeta Talukder,Archana Sharma +2 more
- Vol. 29, Iss: 2, pp 130-140
TLDR
Tobacco, in any combination of chewing mixture, induced time-dependent clastogenicity and direct damage to chromosomes was observed in the early stage, and lethal effects were observed inThe latter stages of the study.Abstract:
Long term studies (up to 10 months) for the simulation of betel habits, with or without tobacco, as currently practiced in Oriental countries, were performed using inbred Swiss albino mice. The cytotoxic and clastogenic potential of these complex chewing mixtures were assessed distally on bone marrow cells. Total aqueous extracts of Areca catechu L. nut and Nicoliana tabacum L. sundried leaf have been found to be mitogenic. The basic ingredients of the quid per se were not clastogenic. Tobacco, in any combination of chewing mixture, induced time-dependent clastogenicity. Direct damage to chromosomes was observed in the early stage, and lethal effects were observed in the latter stages of the study. Nuclear DNA content of the cells, measured in situ by Feulgen cytophotometry, was increased after administration of A. catechu and Piper betle leaf (vars. Bangla and Metha-Thakpala) or any combination of tobacco with or without leaf; nut and lime [Ca(OH)2]. High lime and leaf (var. Bangla) counteracted ...read more
Citations
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Journal ArticleDOI
Plant extracts as modulators of genotoxic effects
TL;DR: Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants, and plant extracts able to modify the process of mutagenesis, which involves alteration in the genetic material are extended.
Book ChapterDOI
Potential Genotoxic and Cytotoxic Effects of Plant Extracts
TL;DR: The medicinal use of plants is probably as old as human kind itself and many of the plants species used for this purpose have been found to contain therapeutic substances which can be extracted and used in preparation of drugs.
Journal ArticleDOI
Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo
TL;DR: The use of green plant parts in modifying the genotoxicity of different agents may be related to the protective action of chlorophyllin, which was tested in vivo on mice bone marrow cells.
Journal ArticleDOI
Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone.
TL;DR: The results indicate that interpretation of adduct frequency values in a risk assessment context can be improved by considering the MI of the target tissue; however, more generalised interpretation is hampered by tissue-specific variations in metabolic capacity and damage processing.
Journal ArticleDOI
MALDI-TOF mass spectrometry analysis of small molecular weight compounds (under 10 KDa) as biomarkers of rat hearts undergoing arecoline challenge.
Tung Sheng Chen,Mu Hsin Chang,Wei Wen Kuo,Yueh Min Lin,Yu Lan Yeh,Cecilia Hsuan Day,Chien Chung Lin,Fuu Jen Tsai,Chang Hai Tsai,Chih Yang Huang +9 more
TL;DR: This study successfully reports a mass-based method for investigating biomarker candidates with small molecular weight in different types of sample (including serum and tissue) and is more time-efficient than gel-based proteomics approach.
References
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Journal ArticleDOI
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
Journal Article
IARC monographs on the evaluation of carcinogenic risk of chemicals to humans.
Higginson J,DeVita Vt +1 more
TL;DR: This documents the current availability of IARC Monographs concerning the carcinogenic risk of chemicals to humans.
Journal ArticleDOI
Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
TL;DR: Several lines of evidence strongly indicate that tobacco-specific nitrosamines have a major role, especially in the causation of oral cancer in snuff-dippers, and should be ideal markers for assessing human exposure to, and metabolic activation of, tobacco smoke carcinogens.
Book
The probability integrals of the range and of the studentized range. probability integral and percentage points of the studentized range; critical values for duncan's new multiple range test
TL;DR: In this article, the authors report critical values (to four significant figures) which have been found by inverse interpolation in the new table of the probability integral of the studentized range.
Journal ArticleDOI
Critical values for duncan's new multiple range test
TL;DR: In this paper, the authors report critical values (to four significant figures) which have been found by inverse interpolation in the new table of the probability integral of the studentized range.