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Inflammatory and Infectious Basis of Atherosclerosis
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TLDR
Antibiotics in the prevention of coronary heart disease: review of the randomised trials and fish oil - a potential therapy for inflammatory atherosclerosis.Abstract:
Atherosclerosis: an inflammatory disease.- Inflammation in coronary atherosclerosis - pathological aspects.- Pathology of acute coronary syndromes.- Transplantation-associated arteriosclerosis and inflammation.- Free radicals as mediators of inflammation in atherosclerosis.- Myocardial reperfusion: a state of inflammation.- LOX-1, a potential inflammatory mediator in atherosclerosis.- Angiotensin II as a mediator of inflammation in atherosclerosis.- Role of interleukins in relation to the renin-angiotensin-system in atherosclerosis.- Heme oxygenase-1, inflammation and atherosclerosis.- Lymphocyte activation in acute coronary syndromes.- Role of infection in atherosclerosis and precipitation of acute cardiac events.- C-reactive protein - a prognostic marker of inflammation in atherothrombosis.- Inflammation as a marker of outcome in myocardial ischemia.- Antibiotics in the prevention of coronary heart disease: review of the randomised trials.- Fish oil - a potential therapy for inflammatory atherosclerosis.read more
Citations
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Journal ArticleDOI
Elevated Chlamydia pneumoniae Antibodies, Cardiovascular Events, and Azithromycin in Male Survivors of Myocardial Infarction
Staci A. Fischer,S Gupta,E Leatham,David Carrington,Michael A. Mendall,Juan Carlos Kaski,A. J. Camm +6 more
TL;DR: An increased anti-Cp antibody titre may be a predictor for further adverse cardiovascular events in post-MI patients and taking a short course of azithromycin may lower this risk, possibly by acting against Cp.
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Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin
IgnatiosIkonomidis,FelicitaAndreotti,EmanouelEconomou,ChristodoulosStefanadis,PavlosToutouzas,PetrosNihoyannopoulos +5 more
TL;DR: This investigation investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.
Journal ArticleDOI
Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in Type 1 diabetic patients.
Sabita S. Soedamah-Muthu,Sabita S. Soedamah-Muthu,Nish Chaturvedi,Casper G. Schalkwijk,Coen D.A. Stehouwer,Pertti Ebeling,John H. Fuller +6 more
TL;DR: In this large sample of Type 1 diabetic patients, it was shown that sVCAM-1 and sE-selectin have positive associations with retinopathy, albuminuria, and CVD, suggesting that adhesion molecules are important in the pathogenesis of vascular complications in Type 1 diabetes.
Journal ArticleDOI
Endothelial cell dysfunction as a novel therapeutic target in atherosclerosis
Hanna Jensen,Jawahar L. Mehta +1 more
TL;DR: This review examines some of the most common associations between therapies of cardiovascular disease and the endothelium, and summarizes the direction of research that may set the stage for one or more interventions targeted to repair damaged and/or dysfunctional endot Helium.
Journal Article
Induction of Early Atherosclerosis in LDL-Receptor–Deficient Mice Immunized With β2-Glycoprotein I
JacobGeorge,ArnonAfek,BorisGilburd,MiriBlank,YairLevy,AnabelAron-Maor,HanaLevkovitz,AvivShaish,IrisGoldberg,JuriKopolovic,DrorHarats,YehudaShoenfeld +11 more
TL;DR: Atherosclerosis was enhanced in the β2GPI-immunized mice (mean aortic lesion, 26 000±5700 μm2) in comparis..., and cholesterol levels did not differ between the mice fed similar diets, regardless of the immunization protocol.
References
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The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
Frank M. Sacks,Marc A. Pfeffer,Lemuel A. Moyé,Jean L. Rouleau,John D. Rutherford,Thomas G. Cole,Lisa E. Brown,J. W. Warnica,J. M. O. Arnold,Chuan Chuan C Wun,Barry R. Davis,Eugene Braunwald +11 more
TL;DR: It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol.