Journal ArticleDOI
Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: a meta-analysis.
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TLDR
Carriers of the SS variant have slightly higher basal FSH levels, tending to require higher doses of exogenous FSH for stimulation, compared with those carrying the Asn/Asn genotype.About:
This article is published in Molecular Genetics and Metabolism.The article was published on 2011-08-01. It has received 62 citations till now. The article focuses on the topics: Follicle-stimulating hormone receptor & Intracytoplasmic sperm injection.read more
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Journal ArticleDOI
Mutations and polymorphisms in FSH receptor: functional implications in human reproduction
TL;DR: The present review discusses the current knowledge of various genetic alterations in FSHR and their impact on receptor function in the female reproductive system and develops molecular markers to predict the optimum dose of FSH required for controlled ovarian hyperstimulation.
Journal ArticleDOI
Genetic predictors of controlled ovarian hyperstimulation: where do we stand today?
TL;DR: Although data are accumulating with evidence suggesting that the ovarian response to COH is mediated by various polymorphisms, the optimal biomarkers and the efficacy of the tests still remain to be evaluated.
Journal ArticleDOI
Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.
Manuela Simoni,Livio Casarini +1 more
TL;DR: The combination of FSHR and FSHB genotypes has a much stronger impact than either one alone in both sexes and may be related to changes in human reproductive strategies and be a marker of some health-related advantage at the cost of reduced fertility.
Journal ArticleDOI
Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis.
Carlo Alviggi,Alessandro Conforti,Daniele Santi,Sandro C. Esteves,Claus Yding Andersen,Peter Humaidan,Paolo Chiodini,Giuseppe De Placido,Manuela Simoni +8 more
TL;DR: The clinical relevance of specific genotype profiles on reproductive outcome is supported and further studies are required to determine their application in a pharmacogenomic approach to ovarian stimulation.
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Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions.
Kristy M. Heppner,Jenny Tong +1 more
TL;DR: In this paper, the authors discuss the current literature on the gluco-regulatory action of the ghrelin system (dAG, AG, GHSR, and GOAT) with specific emphasis aimed toward distinguishing AG vs dAG action.
References
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Journal ArticleDOI
Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure
Kristiina Aittomäki,Kristiina Aittomäki,JoséLuis Dieguez Lucena,JoséLuis Dieguez Lucena,Pirjo Pakarinen,Pertti Sistonen,Juha S. Tapanainen,Jörg Gromoll,Riitta Kaskikari,Eeva-Marja Sankila,Heikki Lehväslaiho,Armando Reyes Engel,Eberhard Nieschlag,Ilpo Huhtaniemi,Albert de la Chapelle +14 more
TL;DR: It is concluded that a mutation in the follicle-stimulating hormone receptor gene causes hypergonadotropic ovarian dysgenesis in multiplex affected families and that the mutation causes ODG in these families.
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The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
TL;DR: This work presents a detailed description of the structure-function relationships and models of FSH-FSH Receptor interaction, and some of the mechanisms behind the interaction between the FSH and FSH receptor have been described.
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Bone Morphogenetic Protein-15 IDENTIFICATION OF TARGET CELLS AND BIOLOGICAL FUNCTIONS
TL;DR: GCs are identified as the first target cells for bone morphogenetic protein-15, and BMP-15 is the first growth factor that can coordinate GC proliferation and differentiation in a way that reflects normal physiology.
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Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype
Maritza Perez Mayorga,Jörg Gromoll,Hermann M. Behre,Claudia Gassner,Eberhard Nieschlag,Manuela Simoni +5 more
TL;DR: Clinical findings demonstrate that the ovarian response to FSH stimulation depends on the FSHR genotype, and the number of ampoules needed could be predicted from a linear combination of both the type of polymorphism and basal FSH levels.
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Genetic and functional analyses of polymorphisms in the human FSH receptor gene
TL;DR: Although F SH receptor polymorphisms have no discernible effect on FSH receptor function in vitro, there are associations between the genotype and some aspects of patient status as suggested by the results of restriction fragment length polymorphism analysis.