The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
Reads0
Chats0
TLDR
This work presents a detailed description of the structure-function relationships and models of FSH-FSH Receptor interaction, and some of the mechanisms behind the interaction between the FSH and FSH receptor have been described.Abstract:
I. Introduction II. Biochemical Properties of the FSH Receptor: A Historical Prelude III. Molecular Structure of the FSH Receptor A. Cloning of the FSH receptor B. Predicted primary structure of the FSH receptor C. Molecular mass of the FSH receptor IV. The FSH Receptor Gene A. Chromosomal localization B. Structure and organization of the FSH receptor gene C. The promoter of the FSH receptor gene V. Expression of the FSH Receptor and Its Regulation A. FSH receptor gene expression B. Expression of the FSH receptor in the testis C. Expression of the FSH receptor in the ovary VI. Expression of the FSH Receptor in Cell Lines A. Cell lines expressing the recombinant FSH receptor B. Measurement of FSH by means of “recombinant” in vitro bioassays C. FSH receptor function in cell lines VII. Structure-Function Relationships and Models of FSH-FSH Receptor Interaction A. General features B. Structure-function relationships C. Models of FSH-FSH receptor interaction VIII. Signal Transduction and Postreceptor Events A....read more
Citations
More filters
Journal ArticleDOI
Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
Andrée Dierich,M. Ram Sairam,Lucia Monaco,Gian Maria Fimia,Anne Gansmuller,Marianne LeMeur,Paolo Sassone-Corsi +6 more
TL;DR: Although FSH signaling is not essential for initiating spermatogenesis, it appears to be required for adequate viability and motility of the sperms and mice lacking FSH-R are generated by homologous recombination.
Journal ArticleDOI
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.
TL;DR: Clinical and experimental genetic disease models form a powerful tool for exploring the physiology and pathophysiology of gonadotropin function and provide an excellent example of the power of molecular biological approaches in the study of pathogenesis of diseases.
Journal ArticleDOI
The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective
TL;DR: In this review, the current knowledge of the structure, functions, and regulation of this important receptor is summarized.
Journal ArticleDOI
Structure of human follicle-stimulating hormone in complex with its receptor
Qing R. Fan,Wayne A. Hendrickson +1 more
TL;DR: The analysis suggests that all glycoprotein hormones bind to their receptors in this mode and that binding specificity is mediated by key interaction sites involving both the common α- and hormone-specific β-subunits.
Journal ArticleDOI
Molecular genetics of the Finnish disease heritage.
TL;DR: Identification of mutated genes has provided tools for detailed analyses of molecular pathogenesis in Finnish diseases, many of which reveal a distinct tissue specificity of clinical phenotype, often providing novel information on biological processes and metabolic pathways essential for normal development and function of human cells and tissues.
References
More filters
Journal ArticleDOI
The scanning model for translation: an update.
TL;DR: The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.
Book ChapterDOI
de la Chapelle, A.
Peter Beighton,Greta Beighton +1 more
TL;DR: De la Chapelle dysplasia, also known as atelosteogenesis type II, is a lethal form of neonatal dwarfism in which gross limb shortening is associated with a characteristic triangular configuration of the radius and ulna.
Journal ArticleDOI
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.
TL;DR: A complete atomic model for bacteriorhodopsin between amino acid residues 8 and 225 has been built and suggests that pK changes in the Schiff base must act as the means by which light energy is converted into proton pumping pressure in the channel.
Journal ArticleDOI
A hot spot of binding energy in a hormone-receptor interface
Tim Clackson,James A. Wells +1 more
TL;DR: The x-ray crystal structure of the complex between human growth hormone and the extracellular domian of its first bound receptor (hGHbp) shows that about 30 side chains from each protein make contact, which resembles a cross section through a globular protein.