Journal ArticleDOI
Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation
C. A. Müller,H. Einsele +1 more
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HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system.Abstract:
HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions.read more
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Journal ArticleDOI
Glycoprotein B genotype correlates with cell tropism in vivo of human cytomegalovirus infection
Ursula Meyer-König,Christian Vogelberg,Angela Bongarts,Danielle Kampa,Regine Delbrück,Guido Wolff-Vorbeck,Günter Kirste,Michael Haberland,Frank T. Hufert,Dorothee von Laer +9 more
TL;DR: Data show that the gB type correlates with viral tropism in vivo and thus provides further evidence thatThe gB variation may indeed influence the virulence of HCMV.
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Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)
M F Roelofs,Mark H. Wenink,Fabia Brentano,Shahla Abdollahi-Roodsaz,Birgitte Oppers-Walgreen,Pilar Barrera,P.L.C.M. van Riel,Leo A. B. Joosten,Diego Kyburz,W.B. van den Berg,Trdj Radstake +10 more
TL;DR: Type I interferons enhance TLR3/TLR7-mediated cytokine production and also TLR4-mediated responses in RA synovium, and are clearly more marked in patients with RA.
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IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients
TL;DR: It is shown for the first time that IL-29 enhances TLR-induced proinflammatory cytokine production in RA-FLS via upregulation of TLRs.
Journal ArticleDOI
7 The role of human cytomegalovirus in haematological diseases
TL;DR: HCMV can infect both haematopoietic progenitor cells and stromal elements, identifying the entire haematography system as a target for HCMV dissemination and latency and exert suppressive effects on immune cell function by direct and indirect mechanisms.
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special considerations for the patient undergoing allogeneic or autologous bone marrow transplantation
John W. Hiemenz,John N. Greene +1 more
TL;DR: Improved diagnosis, treatment, and prevention of infectious complications of bone marrow transplantation over the past two decades have markedly reduced the morbidity and mortality, and early empiric antibiotic coverage with less toxic, but equally effective, antibacterial agents is begun.
References
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Journal Article
Reconstruction of the haemopoietic and immune systems after marrow transplantation.
TL;DR: The kinetics of ontogeny and the defects in the two systems will be described separately, but for clarity, however, the kinetic relationships between the haemopoietic and immune systems should be considered together.
Journal ArticleDOI
Early occurrence of human cytomegalovirus infection after bone marrow transplantation as demonstrated by the polymerase chain reaction technique.
Hermann Einsele,M Steidle,Angelika Vallbracht,Johannes G. Saal,Gerhard Ehninger,Claudia A. Müller +5 more
TL;DR: HCMV was detected in five patients even before the onset of clinical symptoms of acute graft-versus-host disease and could be achieved even in the very early posttransplant period by application of PCR techniques.
Journal ArticleDOI
Epithelial class II antigen expression in cutaneous graft-versus-host disease.
TL;DR: Class II antigen induction is clearly not necessary for the target phase in most patients of this study, and HLA-DR antigen expression was evident in some biopsies with no GVhd or minimal GVHD but did not appear to predict the development of GV HD or the type of GvHD.
Journal ArticleDOI
Immunohistological skin alterations in allogeneic bone marrow transplantation.
TL;DR: In patients with fatal outcome of GvHD prolonged reduction of these dentritic epithelial cells seemed to be indicative of impaired immune reconstitution or bone marrow dysfunction, which may enable early recognition and prognostic evaluation of this disease possibly allowing more effective therapy.