Journal ArticleDOI
Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and hyperreactivity by herbal medicine STA-1.
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TLDR
STA-1 could effectively suppress the Der p 5-induced allergic reactions, and the availability of STA-1 for the treatment of allergic asthma was demonstrated in this study.Abstract:
The availability of STA-1 in suppressing allergen-induced immunoglobulin E (IgE) synthesis, airway inflammation and hyperreactivity in a murine model was investigated. The mice were intraperitoneally sensitized with Dermatophagoides pteronyssinus group 5 allergen (Der p 5) and orally treated with 300 mg/kg of STA-1 every other day for 14 days. The Der p 5-specific immunologic responses including changes of specific immunoglobulin G and E, cells in the broncholarvage fluid, and airway hyperreactivity were measured when mice received inhalation challenge with Der p 5 after sensitization for 21 days. By comparing with sham-treated groups, the synthesis of Der p 5-specific IgE was downregulated while the influx of eosinophils and neutrophils in the airway were remarkably reduced. In addition, Der p 5-induced airway hyperreactivity also was significantly eliminated by STA-1 treatment. These results showed that STA-1 could effectively suppress the Der p 5-induced allergic reactions, and the availability of STA-1 for the treatment of allergic asthma was demonstrated in this study.read more
Citations
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Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy
Xiu-Min Li,L.L. Brown +1 more
TL;DR: Evidence from clinical studies supports beneficial effects of TCM herbal therapy on asthma, and strong preclinical study data suggest the potential efficacy of food allergy herbal formula-2 for food allergy.
Journal ArticleDOI
Traditional Chinese medicine and immune regulation.
TL;DR: Evidence presented in this review reveals the role of TCMs in immune regulation and proposes a promising future for them in immunomodulatory therapies.
Journal ArticleDOI
Traditional Chinese herbal remedies for asthma and food allergy.
TL;DR: This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy.
Journal ArticleDOI
The Immunoregulatory Effects of Traditional Chinese Medicine on Treatment of Asthma or Asthmatic Inflammation
Jinyu Li,Fuchun Zhang,Jinyao Li +2 more
TL;DR: Accumulating evidence suggests that TCM can directly inhibit the activation and migration of inflammatory cells, regulate the balance of Th1/Th2 responses, and suppress allergic hyperreactivity through inducing regulatory T cells or attenuating the function of dendritic cells (DCs).
Journal ArticleDOI
Modulation of antigen-induced anaphylaxis in mice by a traditional Chinese medicine formula, Guo Min Kang.
TL;DR: Systemic anaphylaxis was investigated in mice immediately following Ag challenge, and the results showed that GMK-treated mice from both treatment schedules A and B showed significantly reduced symptom scores when compared with the sham-treated group, suggesting a potential utility of GMK as a prophylactic and therapeutic agent.
References
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Richard Beasley,Julian Crane,Julian Crane,Christopher K.W. Lai,Christopher K.W. Lai,Neil Pearce,Neil Pearce +6 more
TL;DR: Recent research has expanded to include the study of novel factors that may "program" the initial susceptibility to sensitization or contribute to the development of asthma independent of atopic sensitization.
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Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.
TL;DR: It is concluded that neutrophils are the dominant inflammatory leukocyte characterizing airway inflammation in acute severe asthma that requires mechanical ventilation, and that IL-8 is an important mediator of this neutrophilia.